Elevation of Plasma A trial Natriuretic Peptide in a Neurosurgical Patient with the Syndrome of Inappropriate Secretion of Antidiuretic Hormone —Case Report—

Naohito YAMAMOTO; Akio KUWAYAMA; Norihiro MIYAMOTO; Hisao SEO; Nobuo MATSUI

doi:10.2176/nmc.29.255

Elevation of Plasma A trial Natriuretic Peptide in a Neurosurgical Patient with the Syndrome of Inappropriate Secretion of Antidiuretic Hormone

—Case Report—

Naohito YAMAMOTO, Akio KUWAYAMA, Norihiro MIYAMOTO, Hisao SEO, Nobuo MATSUI

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Keywords: hyponatremia, SIADH, cerebral salt wasting, antidiuretic hormone, atrial natriuretic peptide

JOURNAL FREE ACCESS

1989 Volume 29 Issue 3 Pages 255-258

DOI https://doi.org/10.2176/nmc.29.255

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Abstract

The authors describe a case of subarachnoid hemorrhage with hyponatremia accompanied by elevation of plasma atrial natriuretic peptide (ANP). The early phase of hyponatremia was classified as the syndrome of inappropriate secretion of antidiuretic hormone (ADH) due to subarachnoid hemorrhage. However, in the later phase, hyponatremia and natriuresis were accompanied by suppression of ADH while plasma ANP remained elevated. The patient was effectively treated with demeclocycline and hypertonic saline. The significance of ANP in the pathophysiology of increased natriuresis is discussed.

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