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Recent Advances in Anti-Infective Drug Discovery

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ISSN (Print): 2772-4344
ISSN (Online): 2772-4352

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Research Article

Exploring the Potentials of Corn Fiber Gum in Fabricating Mucoadhesive Floating Tablet of Poorly Gastro-retainable Drug

Author(s): Bhumika Mangla, Anurekha Jain* and Deepinder S. Malik*

Volume 16, Issue 1, 2021

Published on: 11 November, 2020

Page: [13 - 29] Pages: 17

DOI: 10.2174/1574891X15999201111200523

Price: $65

Abstract

Aim: To formulate and preliminary evaluated polysaccharide based mucoadhesive floating tablets of Cinnarizine.

Background: Gastro-retentive drug delivery systems has proved to be a successful approach to enhance the gastric residence with site specific targeting for achieving local or generalized effect. Various patents has also been filed globally employing gastro-retentive approach.

Objective: The study is designed to explore the mucoadhesive and low density characteristics of corn fibre gum (CFG) for the preparation of gastro-retentive floating tablets of cinnarizine.

Methods: Floating tablets were prepared by direct compression technique using different concentrations of CFG (45, 50, 60% w/w). The formulated floating tablet batches were evaluated for their hardness, friability, drug content, floating duration/lag time, swelling behavior, bioadhesive strength and in-vitro drug release.

Results: Mucoadhesive strength was found to increase with an increment in the polysaccharide concentration. Swelling index was found to increase both with the increase in CFG concentration and with duration for which tablet remains in medium. The in-vitro drug release studies indicated decrease in drug release (91% to 77%) with the increase in polymer concentration. The release data was further fitted to various kinetic models which revealed the drug release to be in accordance with zero order and Higuchi models, indicating polymer to exhibit the swellable matrix forming abilities. The value of n (between 0.458 and 0.997) from Korsemeyer-Peppas model depicted the possibility of drug to follow more than one mechanism of release from the formulation i.e. diffusion and erosion. Stability studies revealed the preparations to retain their integrity and pharmaceutical characteristics at variable storage conditions.

Conclusion: Thus from the research findings, CFG could be concluded to possess potential binder, release retardant and mucoadhesive characteristics which could be successfully employed for the formulation of gastro-retentive floating tablets.

Keywords: Binding agent, corn fibre gum, cinnarizine, drug release mechanisms, floating tablets, mucoadhesive strength, release retardant.

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[1]
Nayak, A.K.; Das, M.R.B. Gastroretentive drug delivery systems. Asian J. Pharm. Clin. Res, 2010, 3, 2-10.
[2]
Nagarwal, R.C.; Ridhurkar, D.N.; Pandit, J.K. In vitro release kinetics and bioavailability of gastroretentive cinnarizine hydrochloride tablet. AAPS PharmSciTech, 2010, 11(1), 294-303.
[http://dx.doi.org/10.1208/s12249-010-9380-5] [PMID: 20182827]
[3]
Karwa Preeti, V.; Kasturi, P.V. Formulation and evaluation of controlled floating matrix tablets of a weakly basic drug cinnarizine. J. Pharm. Res., 2011, 4, 2665-2669.
[4]
Kumar, V.; Ahmad, S.; Singh, R.B. Gastroretentive tablets. U.S. Patent 9,393,205, 2016.
[5]
Kamboj, S.; Rana, V. Physicochemical, rheological and antioxidant potential of corn fiber gum. Food Hydrocoll., 2014, 39, 1-9.
[http://dx.doi.org/10.1016/j.foodhyd.2013.12.015]
[6]
Patnaik, A.R.; Mantry, S.H. Formulation and evaluation of gastroretentive floating microsphere of cinnarizine. Asian J. Pharm. Clin. Res., 2012, 5, 100-109.
[7]
Nagarsenker, M.S.; Garad, S.D.; Ramprakash, G. Design, optimization and evaluation of domperidone coevaporates. J. Control. Release, 2000, 63(1-2), 31-39.
[http://dx.doi.org/10.1016/S0168-3659(99)00177-7] [PMID: 10640578]
[8]
Kalava, S.B.; Demirel, M.; Odabası, H.F. Physicochemical characterization and dissolution properties of cinnarizine solid dispersions. Turkish J. Pharm. Sci, 2005, 2, 51-62.
[9]
Patel, N.V.; Rathod, M.L. Preparation of microspherical particles of cinnarizine hydrochloride/polyvinylpyrrolidone K29-32 using spray drying method. Pharma Sci. Monitor, 2017, 8, 291-301.
[10]
Reddy, Y.K.; Kumar, K.S. Formulation and Evaluation of Effervescent Floating Tablets of Domperidone. Asian J. Res. Pharm. Sci., 2020, 10, 1-5.
[http://dx.doi.org/10.5958/2231-5659.2020.00001.6]
[11]
Raut Indrayani, D.; Bandgar Sandip, A.; Shah, R.R.; Chougule, D.D. Formulation and Evaluation of Gastric Floating Tablet of Domperidone. Asian J. Res. Pharm. Sci., 2014, 4, 22-25.
[12]
Rangapriya, M.; Manigandan, V.; Natarajan, R.; Mohankumar, K. Formulation and evaluation of floating tablets of Pioglitazone hydrochloride. Int. J. Pharm. Chem. Sci., 2012, 1, 1046-1054.
[13]
Gaikwad, S.S.; Avari, J.G. Improved bioavailability of Azelnidipine gastro retentive tablets-optimization and in-vivo assessment. Mater. Sci. Eng. C, 2019, 103109800
[http://dx.doi.org/10.1016/j.msec.2019.109800] [PMID: 31349458]
[14]
Gharti, K.; Thapa, P.; Budhathoki, U.; Bhargava, A. Formulation and in vitro evaluation of floating tablets of hydroxypropyl methylcellulose and polyethylene oxide using ranitidine hydrochloride as a model drug. J. Young Pharm., 2012, 4(4), 201-208.
[http://dx.doi.org/10.4103/0975-1483.104363] [PMID: 23493037]
[15]
Hardikar, S.; Bhosale, A. Formulation and evaluation of oral dispersible tablets of cinnarizine using direct compression technique. Int J Pharm Sci Res, 2018, 56, 147-157.
[http://dx.doi.org/10.1016/j.bfopcu.2018.07.001]
[16]
Patel, N.J.; Lakshmi, C.S.R.; Patel, H.P.; Akul, S. Formulation and evaluation of Oral dispersible tablets of cinnarizine using direct compression technique. Int. J. Pharm. Sci. Res., 2011, 2, 961-967.
[17]
Kumar, M.V.; Krishnarajan, D.; Manivannan, R.; Parthiban, K.G. Formulation and evaluation of bi-layer domperidone floating tablets. Int. J. Pharm. Sci. Res., 2011, 2, 2217-2225.
[18]
Korsmeyer, R.W.; Gurny, R.; Doelkar, E.; Buri, P.; Peppas, N.A. Mechanism of solute release from porous hydrophilic polymers. Int. J. Pharm., 1983, 15, 25-35.
[http://dx.doi.org/10.1016/0378-5173(83)90064-9]
[19]
Venkateswarlu, K. Formulation development and in-vitro evaluation of floating tablets of ciprofloxacin HCl. Asian J. Pharm, 2016, 10, 271-278.
[20]
Tarkase, K.N.; Tarkase, M.K.; Dokhe, M.D.; Wagh, V.S. Development and validation of spectrophotometric method for simultaneous estimation of cinnarizine and domperidone maleate in pure and tablet dosage form. Int. J. Pharm. Sci. Res., 2012, 3, 2700-2704.
[21]
Gupta, S.; Madan, R.N.; Bansal, M.C. Chemical composition of Pinus caribaea hemicellulose. Tappi J., 1987, 70, 113-114.
[22]
Mehta, D.M.; Parejiya, P.B.; Barot, B.S.; Shelat, P.K. Investigation of the drug release modulating effect of acidifiers in modified release oral formulation of cinnarizine. Asian J. Pharm. Sci., 2012, 7, 193-201.
[23]
Mészáros, E.; Jakab, E.; Gaspar, M.; Reczey, K.; Várhegyi, G. Thermal behavior of corn fibers and corn fiber gums prepared in fiber processing to ethanol. J. Anal. Appl. Pyrolysis, 2009, 85, 11-18.
[http://dx.doi.org/10.1016/j.jaap.2008.10.004]
[24]
Sisinthy, S.P.; Selladurai, S. Cinnarizine liquid solid compacts: preparation evaluation. Int. J. Appl. Pharm, 2019, 11, 150-157.
[http://dx.doi.org/10.22159/ijap.2019v11i1.30109]
[25]
Ovenseri, A.C.; Michael, U.U. Research Article Formulation and Evaluation of Effervescent Floating Matrix Tablets of a Biguanide Using Grewia mollis Gum. Asian J. Appl. Sci., 2019, 12, 91-98.
[http://dx.doi.org/10.3923/ajaps.2019.91.98]
[26]
Shahzad, Y.; Ibrar, N.; Hussain, T.; Yousaf, A.M.; Khan, I.U.; Rizvi, S.A. Relevancy of nizatidine release from floating tablets with viscosity of various cellulose ethers. Sci, 2019, 1, 22-30.
[http://dx.doi.org/10.3390/sci1010022]
[27]
Goole, J.; Vanderbist, F.; Amighi, K. Development and evaluation of new multiple-unit levodopa sustained-release floating dosage forms. Int. J. Pharm., 2007, 334(1-2), 35-41.
[http://dx.doi.org/10.1016/j.ijpharm.2006.10.018] [PMID: 17097841]
[28]
Singh, B.; Garg, B.; Chaturvedi, S.C.; Arora, S.; Mandsaurwale, R.; Kapil, R.; Singh, B. Formulation development of gastroretentive tablets of lamivudine using the floating-bioadhesive potential of optimized polymer blends. J. Pharm. Pharmacol., 2012, 64(5), 654-669.
[http://dx.doi.org/10.1111/j.2042-7158.2011.01442.x] [PMID: 22471361]
[29]
Giri, P.; Singh, I. Development and evaluation of mucoadhesive tablets of cinnarizine using carboxymethylated guar gum by compression coating technique. Biointerface Res. Appl. Chem., 2020, 10, 6365-6376.
[http://dx.doi.org/10.33263/BRIAC105.63656376]
[30]
Porwal, A.; Dwivedi, H.; Pathak, K. Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy. Braz. J. Pharm. Sci., 2017, 53, 1-15.
[http://dx.doi.org/10.1590/s2175-97902017000300173]
[31]
Pawar, H.A.; Gharat, P.R.; Dhavale, R.V.; Joshi, P.R.; Rakshit, P.P. Development and evaluation of gastroretentive floating tablets of an antihypertensive drug using hydrogenated cottonseed oil. ISRN Pharm., 2013, 2013137238
[http://dx.doi.org/10.1155/2013/137238] [PMID: 24455312]
[32]
Srivastava, A.K.; Ridhurkar, D.N.; Wadhwa, S. Floating microspheres of cimetidine: formulation, characterization and in vitro evaluation. Acta Pharm., 2005, 55(3), 277-285.
[PMID: 16375838]
[33]
Ammar, H.O.; Ghorab, M.; Kamel, R.; Salama, A.H. Design and optimization of gastro-retentive microballoons for enhanced bioavailability of cinnarizine. Drug Deliv. Transl. Res., 2016, 6(3), 210-224.
[http://dx.doi.org/10.1007/s13346-016-0280-4] [PMID: 26832133]
[34]
Fuchs, H.U. The dynamics of heat: A unified approach to thermodynamics and heat transfer New York: Springer, 2010; pp. 265-266.
[35]
Delcour, J.; Degeest, C.; Hoseney, R.C.; Shelke, K. Glycine Derivatives as the Source of Carbon-Dioxide in Cake Formulations. Cereal Chem., 1991, 68, 369-371.
[36]
Hasçiçek, C.; Yüksel-Tilkan, G.; Türkmen, B.; Ozdemir, N. Effect of formulation parameters on the drug release and floating properties of gastric floating two-layer tablets with acetylsalicylic acid. Acta Pharm., 2011, 61(3), 303-312.
[http://dx.doi.org/10.2478/v10007-011-0028-0] [PMID: 21945909]
[37]
Singh, K.; Kumar, A.; Langyan, N.; Ahuja, M. Evaluation of Mimosa pudica seed mucilage as sustained-release excipient. AAPS PharmSciTech, 2009, 10(4), 1121-1127.
[http://dx.doi.org/10.1208/s12249-009-9307-1] [PMID: 19763837]

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