Abstract
To evaluate the relationship between Chlamydia pneumoniae infection and lung cancer, we conducted a metaanalysis of studies comparing the antibodies of C. pneumoniae between lung cancer patients and controls. The random-effects model or fixed-effects model was used according to the results of heterogeneity tests. Total, 8 studies with 1602 cases and 1734 controls were included. The analysis showed that the pooled OR of the association between C. pneumoniae IgA and lung cancer was 1.82 (95% CI, 1.21-2.74), while the association between C. pneumoniae IgG and lung cancer was 1.77 (95% CI, 1.13-2.78). Thus, statistically significant differences were observed between C. pneumoniae antibodies and lung cancer. This meta-analysis suggests that C. pneumoniae infection may be a potential risk factor for lung cancer.
Keywords: Chlamydia pneumoniae, lung cancer, meta-analysis
Current Respiratory Medicine Reviews
Title: Association Between Chlamydia pneumoniae Antibodies and Lung Cancer: A Meta-Analysis
Volume: 6 Issue: 3
Author(s): Zhuang Liu, Zhi-hua Yin, Hui-ying Liang, Zhi-fang Jia and Bao-sen Zhou
Affiliation:
Keywords: Chlamydia pneumoniae, lung cancer, meta-analysis
Abstract: To evaluate the relationship between Chlamydia pneumoniae infection and lung cancer, we conducted a metaanalysis of studies comparing the antibodies of C. pneumoniae between lung cancer patients and controls. The random-effects model or fixed-effects model was used according to the results of heterogeneity tests. Total, 8 studies with 1602 cases and 1734 controls were included. The analysis showed that the pooled OR of the association between C. pneumoniae IgA and lung cancer was 1.82 (95% CI, 1.21-2.74), while the association between C. pneumoniae IgG and lung cancer was 1.77 (95% CI, 1.13-2.78). Thus, statistically significant differences were observed between C. pneumoniae antibodies and lung cancer. This meta-analysis suggests that C. pneumoniae infection may be a potential risk factor for lung cancer.
Export Options
About this article
Cite this article as:
Liu Zhuang, Yin Zhi-hua, Liang Hui-ying, Jia Zhi-fang and Zhou Bao-sen, Association Between Chlamydia pneumoniae Antibodies and Lung Cancer: A Meta-Analysis, Current Respiratory Medicine Reviews 2010; 6 (3) . https://dx.doi.org/10.2174/157339810791526111
DOI https://dx.doi.org/10.2174/157339810791526111 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Epigenetic Aberrations and Targeted Epigenetic Therapy of Esophageal Cancer
Current Cancer Drug Targets vHTS, 3-D Pharmacophore, QSAR and Molecular Docking Studies for the Identification of Phyto-derived ATP-Competitive Inhibitors of the BCR-ABL Kinase Domain
Current Drug Discovery Technologies Retinoid Receptors in Inflammatory Responses: A Potential Target for Pharmacology
Current Drug Targets - Inflammation & Allergy Role of Tyrosine Kinase Inhibitors in Lung Cancer
Anti-Cancer Agents in Medicinal Chemistry Human Serum Albumin Conjugated Biomolecules for Cancer Molecular Imaging
Current Pharmaceutical Design Current Perspective of Natural Alkaloid Carbazole and its Derivatives as Antitumor Agents
Anti-Cancer Agents in Medicinal Chemistry Natural Antibodies: Protecting Role of IgM in Glioblastoma and Brain Tumours
Current Pharmaceutical Design Chemokines as Therapeutic Targets in Non-Small Cell Lung Cancer
Current Medicinal Chemistry - Anti-Cancer Agents Pathways Related to the Anti-Cancer Effects of Metabolites Derived from Cerrado Biome Native Plants: An Update and Bioinformatics Analysis on Oral Squamous Cell Carcinoma
Protein & Peptide Letters Targeting the Most Upstream Site of Wnt Signaling Pathway Provides a Strategic Advantage for Therapy in Colorectal Cancer
Current Drug Targets Target Acquired: Progress and Promise of Targeted Therapeutics in the Treatment of Prostate Cancer
Current Cancer Drug Targets ABC Transporters: Unvalidated Therapeutic Targets in Cancer and the CNS
Anti-Cancer Agents in Medicinal Chemistry The Role of ABC Transporters in Protecting Cells from Bilirubin Toxicity
Current Pharmaceutical Design Follow the ATP: Tumor Energy Production: A Perspective
Anti-Cancer Agents in Medicinal Chemistry Down Regulation of Differentiated Embryo-Chondrocyte Expressed Gene 1 is Related to the Decrease of Osteogenic Capacity
Current Drug Targets Structure-Activity Relationship Studies on Holy Basil (Ocimum sanctum L.) Based Flavonoid Orientin and its Analogue for Cytotoxic Activity in Liver Cancer Cell Line HepG2
Combinatorial Chemistry & High Throughput Screening Sumoylation in Cellular Senescence and Aging
Current Molecular Medicine p73 as a Pharmaceutical Target for Cancer Therapy
Current Pharmaceutical Design Patented Biomarker Panels in Early Detection of Cancer
Recent Patents on Biomarkers Status of Flavonols as P-Glycoprotein Inhibitors in Cancer Chemotherapy
Current Cancer Therapy Reviews