Abstract
The purpose of this study was to evaluate the efficacy of newly synthesized bibenzoimidazolyl derivatives 2(ai) as antimicrobials. These molecules are obtained by the reaction of different pharmaceutically important bioactive aralkyl halides with 1, 7-dimethyl-2-propyl-1H, 3H-[2, 5]bibenzoimidazole in presence of powdered potassium carbonate in DMF solvent under both conventional and microwave methods. The microwave method offers the products 2(a-i) in higher yields compared to conventional method. All the synthesized compounds were characterized by IR, 1H NMR and elemental analysis and evaluated their efficacy as antimicrobials. We observed the significant differences between the antimicrobial activities of the newly synthesized compounds based on their various substituents present at N1 position. Compounds 2h, 2a, 2c, 2e and 2f showed potent antimicrobial activity compared to standard drugs.
Keywords: Bibenzoimidazole, N-alkylation, Microwave, Antimicrobials
Letters in Drug Design & Discovery
Title: Microwave-Assisted Synthesis of N-Alkylated Bibenzoimidazolyl Derivatives: Antimicrobial Studies
Volume: 6 Issue: 5
Author(s): S. Nanjunda Swamy, C. V. Kavitha, B. S. Priya, S. L. Gaonkar, M. V. Tejesvi and K. S. Rangappa
Affiliation:
Keywords: Bibenzoimidazole, N-alkylation, Microwave, Antimicrobials
Abstract: The purpose of this study was to evaluate the efficacy of newly synthesized bibenzoimidazolyl derivatives 2(ai) as antimicrobials. These molecules are obtained by the reaction of different pharmaceutically important bioactive aralkyl halides with 1, 7-dimethyl-2-propyl-1H, 3H-[2, 5]bibenzoimidazole in presence of powdered potassium carbonate in DMF solvent under both conventional and microwave methods. The microwave method offers the products 2(a-i) in higher yields compared to conventional method. All the synthesized compounds were characterized by IR, 1H NMR and elemental analysis and evaluated their efficacy as antimicrobials. We observed the significant differences between the antimicrobial activities of the newly synthesized compounds based on their various substituents present at N1 position. Compounds 2h, 2a, 2c, 2e and 2f showed potent antimicrobial activity compared to standard drugs.
Export Options
About this article
Cite this article as:
Swamy Nanjunda S., Kavitha V. C., Priya S. B., Gaonkar L. S., Tejesvi V. M. and Rangappa S. K., Microwave-Assisted Synthesis of N-Alkylated Bibenzoimidazolyl Derivatives: Antimicrobial Studies, Letters in Drug Design & Discovery 2009; 6 (5) . https://dx.doi.org/10.2174/1570180810906050380
DOI https://dx.doi.org/10.2174/1570180810906050380 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Modifying Anti-Inflammatory Effect of Diclofenac with Murraya koenigii
Recent Patents on Inflammation & Allergy Drug Discovery The Diagnostic and Prognostic Value of Brain Natriuretic Peptide and Aminoterminal (nt)-pro Brain Natriuretic Peptide
Current Pharmaceutical Design Expeditious and Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by Nano-MgO
Letters in Organic Chemistry HSP70 Family in the Renal Inflammatory Response
Inflammation & Allergy - Drug Targets (Discontinued) Recent Patents on Eggshell: Shell and Membrane Applications
Recent Patents on Food, Nutrition & Agriculture Anti-VEGF Treatment of Glaucoma
Current Drug Therapy Current Strategies and Future Perspective for the Effective Treatment of Diabetic Retinopathy
Current Drug Therapy Endothelial Dysfunction and Inflammatory Markers of Vascular Disease
Current Vascular Pharmacology Effects of Antiplatelet Medication on Arteriovenous Fistula Patency After Surgical Thrombectomy
Current Vascular Pharmacology Current Advances in the Biological Activity of Polysaccharides in Dendrobium with Intriguing Therapeutic Potential
Current Medicinal Chemistry Role of Inflammatory Cells and Toll-Like Receptors in Atherosclerosis
Current Vascular Pharmacology Anti-HER2 Therapy in Elderly Breast Cancer Patients
Reviews on Recent Clinical Trials Utility of MLH1 Methylation Analysis in the Clinical Evaluation of Lynch Syndrome in Women with Endometrial Cancer
Current Pharmaceutical Design Adrenomedullins: Therapeutic Potential in Cardiovascular Disease
Current Hypertension Reviews Beneficial Effects of Corn Silk on Metabolic Syndrome
Current Pharmaceutical Design Endocannabinoid System: A Multi-Facet Therapeutic Target
Current Clinical Pharmacology Research Progress on Pathogenesis of Obesity-Induced Insulin Resistance and Its Therapeutic Targets: PPARα/γ
Current Signal Transduction Therapy Complementary Role of Herbal Medicine and Exercise in Cardiovascular Disease Prevention and Management: A Review of Evidence
Current Pharmaceutical Design TNF-α and IL-8 in Acute Stroke and the Modulation of these Cytokines by Antiplatelet Agents
Current Neurovascular Research Stem Cell Gene Therapy for Chronic Renal Failure
Current Gene Therapy