3D-QSAR Study on Ring Substituted Imidazoles for Their Antitubercular Activity

Title: 3D-QSAR Study on Ring Substituted Imidazoles for Their Antitubercular Activity

Volume: 7 Issue: 2

Author(s): Gyanendra Kumar Sharma and Devender Pathak

Affiliation:

Keywords: Ring substituted imidazoles, Antitubercular activity, CoMFA, 3D-QSAR

Abstract: Ring substituted imidazoles are the emerging class of antitubercular agents. CoMFA model for various ring substituted imidazoles is used to elucidate their structure activity relationships. Both the training set and test set compounds were modeled to the established procedures and were aligned. There was a good correlation between the predicted and experimental activities for both the test set and training set compounds by CoMFA model. Structure activity relations have been established based on the obtained contour maps from the 3D-QSAR analysis.

Cite this article as:

Sharma Kumar Gyanendra and Pathak Devender, 3D-QSAR Study on Ring Substituted Imidazoles for Their Antitubercular Activity, Letters in Drug Design & Discovery 2010; 7 (2) . https://dx.doi.org/10.2174/157018010790225912