A Novel, Unusual Acid Catalyzed Route to Substituted 1,4-dihydropyridine via Double Decarboxylation

Title: A Novel, Unusual Acid Catalyzed Route to Substituted 1,4-dihydropyridine via Double Decarboxylation

Volume: 8 Issue: 9

Author(s): Jacob Porter, Graham Radomski, Joel Seagren, Benjamin Batura and Samuel David

Affiliation:

Keywords: 3,4,5-trisubstituted, 1,4-dihydropyridines, double decarboxylation, enamine, heterocycles, intermolecular condensation, tandem reaction, nifedipine), calcium, ethylidene, dimethyl

Abstract: A simple and high yield route to 3,4,5-trisubstituted 1,4-dihydropyridine systems via an interesting intermolecular condensation and double decarboxylation is described.

Cite this article as:

Porter Jacob, Radomski Graham, Seagren Joel, Batura Benjamin and David Samuel, A Novel, Unusual Acid Catalyzed Route to Substituted 1,4-dihydropyridine via Double Decarboxylation, Letters in Organic Chemistry 2011; 8 (9) . https://dx.doi.org/10.2174/157017811799304278