Enantioselective Michael Addition of Nitroolefins and Cyclohexanones Catalyzed by Novel Pyrrolidine-thiourea Bifunctional Catalysts with Two Chiral Centers

Title: Enantioselective Michael Addition of Nitroolefins and Cyclohexanones Catalyzed by Novel Pyrrolidine-thiourea Bifunctional Catalysts with Two Chiral Centers

Volume: 5 Issue: 5

Author(s): Dongping Cheng and Weiliang Bao

Affiliation:

Keywords: Asymmetric catalysis, Michael addition, asymmetric synthesis, pyrrolidine-thiourea bifunctional catalyst, nitroolefin, cyclohexanone

Abstract: Catalyzed by the novel pyrrolidine-thiourea bifunctional catalysts with two chiral centers, the asymmetric Michael addition of nitroolefins and cyclohexanones was successfully performed. A wide range of the products were obtained in good to excellent enantioselectivies and diastereoselectivities.

Cite this article as:

Cheng Dongping and Bao Weiliang, Enantioselective Michael Addition of Nitroolefins and Cyclohexanones Catalyzed by Novel Pyrrolidine-thiourea Bifunctional Catalysts with Two Chiral Centers, Letters in Organic Chemistry 2008; 5 (5) . https://dx.doi.org/10.2174/157017808784872151