Abstract
Anion transport across phospholipid membrane is a typical supramolecular function involving dynamic recognition of the substrate during the whole translocation process. Supramolecular chemists, taking inspiration by the natural anion transporters, have designed artificial systems able to mimic, at the functional level, several features of the natural ion channels. The scope of this research is twofold: on one hand to get insight on the molecular basis of recognition and transport, and on the other hand to get control of the biomedical relevant processes. The present review focuses on the synthetic systems promoting anion transport, covering both artificial channels and carriers that operate in phospholipid membrane. The design principles of such systems will be discussed together with the potential biomedical applications.
Keywords: Anion transport, ion channels, ion carriers, ionophores, bilayer membranes, biomimetic models, supramolecular chemistry
Current Drug Discovery Technologies
Title: Artificial Anion Transporters in Bilayer Membranes
Volume: 5 Issue: 2
Author(s): Sabina Licen, Francesco De Riccardis, Irene Izzo and Paolo Tecilla
Affiliation:
Keywords: Anion transport, ion channels, ion carriers, ionophores, bilayer membranes, biomimetic models, supramolecular chemistry
Abstract: Anion transport across phospholipid membrane is a typical supramolecular function involving dynamic recognition of the substrate during the whole translocation process. Supramolecular chemists, taking inspiration by the natural anion transporters, have designed artificial systems able to mimic, at the functional level, several features of the natural ion channels. The scope of this research is twofold: on one hand to get insight on the molecular basis of recognition and transport, and on the other hand to get control of the biomedical relevant processes. The present review focuses on the synthetic systems promoting anion transport, covering both artificial channels and carriers that operate in phospholipid membrane. The design principles of such systems will be discussed together with the potential biomedical applications.
Export Options
About this article
Cite this article as:
Licen Sabina, Riccardis De Francesco, Izzo Irene and Tecilla Paolo, Artificial Anion Transporters in Bilayer Membranes, Current Drug Discovery Technologies 2008; 5 (2) . https://dx.doi.org/10.2174/157016308784746319
DOI https://dx.doi.org/10.2174/157016308784746319 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Memories are Made of This (Perhaps): A Review of Serotonin 5-HT6 Receptor Ligands and Their Biological Functions
Current Topics in Medicinal Chemistry Sleep, Depression and Insomnia – A Vicious Circle?
Current Psychiatry Reviews The Psychoactive Effects of Aromatic Amino Acids
Current Nutrition & Food Science Editorial: Obstructive Sleep Apnea (OSA) in the Elderly: Does OSA Decrease Mortality in These Patients When They Have Pneumonia?
Current Respiratory Medicine Reviews On the Use of Hydrogels in Cell Encapsulation and Tissue Engineering Systems
Recent Patents on Drug Delivery & Formulation Physiological Insights Derived from Mathematical Models of Respiration
Current Respiratory Medicine Reviews Cognitive-Behavioral Therapy for Youth with Obsessive-Compulsive and Related Disorders
Current Psychiatry Reviews Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases
Current Pharmaceutical Design The Effects of Vitamin B in Depression
Current Medicinal Chemistry Antinociceptive Effects of Aza-Bicyclic Isoxazoline-Acylhydrazone Derivatives in Different Models of Nociception in Mice
Current Topics in Medicinal Chemistry Molecular Imaging of Stem Cell Transplantation for Neurodegenerative Diseases
Current Pharmaceutical Design Arterial Spin Labeling Perfusion MRI in Alzheimers Disease
Current Medical Imaging Non-viral Gene Delivery and Therapeutics Targeting to Brain
Current Nanoscience Vitiligo: An Updated Narrative Review
Current Pediatric Reviews Pathological Gambling in Parkinson’s Disease: An Update on Medical Management
Current Psychopharmacology Anterior Labial Alveolar Bone Thickness after Orthodontic Retraction of Anterior Teeth
Current Dentistry Interaction Between Bone and Muscle in Older Persons with Mobility Limitations
Current Pharmaceutical Design Thermal Adaptation of Heat Shock Proteins
Current Protein & Peptide Science Aurora-B Kinase Inhibitors for Cancer Chemotherapy
Mini-Reviews in Medicinal Chemistry Nano-Neurotherapeutics (NNTs): An Emergent and Multifaceted Tool for CNS Disorders
Current Drug Metabolism