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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

Affective and Cognitive Impairments in Rodent Models of Diabetes

Author(s): Enza Palazzo*, Ida Marabese, Serena Boccella, Carmela Belardo, Gorizio Pierretti and Sabatino Maione

Volume 22, Issue 8, 2024

Published on: 24 January, 2024

Page: [1327 - 1343] Pages: 17

DOI: 10.2174/1570159X22666240124164804

Price: $65

Abstract

Diabetes and related acute and long-term complications have a profound impact on cognitive, emotional, and social behavior, suggesting that the central nervous system (CNS) is a crucial substrate for diabetic complications. When anxiety, depression, and cognitive deficits occur in diabetic patients, the symptoms and complications related to the disease worsen, contributing to lower quality of life while increasing health care costs and mortality. Experimental models of diabetes in rodents are a fundamental and valuable tool for improving our understanding of the mechanisms underlying the close and reciprocal link between diabetes and CNS alterations, including the development of affective and cognitive disorders. Such models must reproduce the different components of this pathological condition in humans and, therefore, must be associated with affective and cognitive behavioral alterations. Beyond tight glycemic control, there are currently no specific therapies for neuropsychiatric comorbidities associated with diabetes; animal models are, therefore, essential for the development of adequate therapies. To our knowledge, there is currently no review article that summarizes changes in affective and cognitive behavior in the most common models of diabetes in rodents. Therefore, in this review, we have reported the main evidence on the alterations of affective and cognitive behavior in the different models of diabetes in rodents, the main mechanisms underlying these comorbidities, and the applicable therapeutic strategy.

Keywords: Diabetes, animal models, rodents, anxiety, depression, cognitive deficits.

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