Abstract
Metabolomics represents the global profiling of metabolites in a given biological system. It has been used to facilitate pharmaceutical discovery and development for over a decade. Advances in instrumentation have positioned capillary electrophoresis–mass spectrometry (CE-MS) as an important platform for both targeted and non-targeted metabolomics. In this mini-review covering the last five years, we focus on the latest development of CE-MS based metabolomics in (a) identification and validation of novel valuable therapeutic targets, (b) evaluation of drug efficacy, and (c) monitoring of drug unanticipated adverse effects. Some of the current issues and future directions of CE-MS metabolomics are also discussed in the end.
Keywords: Biomarkers, CE-MS, drug discovery and development, drug efficacy, drug toxicity metabolomics.
Current Drug Metabolism
Title:Capillary Electrophoresis–Mass Spectrometry in Metabolomics: The Potential for Driving Drug Discovery and Development
Volume: 14 Issue: 7
Author(s): Xu Wang, Kefeng Li, Erwin Adams and Ann Van Schepdael
Affiliation:
Keywords: Biomarkers, CE-MS, drug discovery and development, drug efficacy, drug toxicity metabolomics.
Abstract: Metabolomics represents the global profiling of metabolites in a given biological system. It has been used to facilitate pharmaceutical discovery and development for over a decade. Advances in instrumentation have positioned capillary electrophoresis–mass spectrometry (CE-MS) as an important platform for both targeted and non-targeted metabolomics. In this mini-review covering the last five years, we focus on the latest development of CE-MS based metabolomics in (a) identification and validation of novel valuable therapeutic targets, (b) evaluation of drug efficacy, and (c) monitoring of drug unanticipated adverse effects. Some of the current issues and future directions of CE-MS metabolomics are also discussed in the end.
Export Options
About this article
Cite this article as:
Wang Xu, Li Kefeng, Adams Erwin and Schepdael Van Ann, Capillary Electrophoresis–Mass Spectrometry in Metabolomics: The Potential for Driving Drug Discovery and Development, Current Drug Metabolism 2013; 14 (7) . https://dx.doi.org/10.2174/13892002113149990101
DOI https://dx.doi.org/10.2174/13892002113149990101 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
Tissue Distribution and Metabolism of Micro- and Nanoparticles and Medical Implants
With the continuous advancement of modern science and engineering, numerous functional materials and active molecules have been developed and utilized in various industrial, medical, and food applications. Many of these can enter the body, either actively or passively, and have significant and intricate impacts on human health. For example, biomaterials ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nanocarriers as Prospective Approach in Effective Management of Acne Vulgaris
Micro and Nanosystems Organoids as <i>Ex Vivo</i> Culture System to Investigate Infection-host Interaction in Gastric Pre-carcinogenesis
Recent Advances in Inflammation & Allergy Drug Discovery Cyclooxygenase-2 Inhibition and Gastric Cancer
Current Pharmaceutical Design Strategies Targeting DNA Topoisomerase I in Cancer Chemotherapy: Camptothecins, Nanocarriers for Camptothecins, Organic Non-Camptothecin Compounds and Metal Complexes
Current Drug Targets Molecular Treatment of Different Breast Cancers
Anti-Cancer Agents in Medicinal Chemistry Recent Progress on Apoptotic Activity of Triazoles
Current Drug Targets Essential Role of Gli Proteins in Glioblastoma Multiforme
Current Protein & Peptide Science Metabolic Syndrome X is a Low-Grade Systemic Inflammatory Condition with its Origins in the Perinatal Period
Current Nutrition & Food Science Cannabinoids
Current Drug Targets - CNS & Neurological Disorders Epigenetic Modifications of the Nuclear Factor Kappa B Signalling Pathway and its Impact on Inflammatory Bowel Disease
Current Pharmaceutical Design Relation Between Helicobacter Pylori Infection and Gastroduodenal Diseases
Current Cancer Therapy Reviews Chitosan Applications on Pharmaceutical Sciences: A Review
Drug Delivery Letters Role of Radiopharmaceuticals in Development of Inhaled Drugs
Current Pharmaceutical Design Treatment of Psoriasis: A Comprehensive Review of Entire Therapies
Current Drug Safety Biophysical Characterization of Antimicrobial Peptides Activity: From In Vitro to Ex Vivo Techniques
Current Protein & Peptide Science General Principles of Photodynamic Therapy (PDT) and Gastrointestinal Applications
Current Pharmaceutical Biotechnology IBD Modern Concepts, Nano Drug Delivery and Patents: An Update
Recent Patents on Nanomedicine Patented Bioavailability Enhancement Techniques of Silymarin
Recent Patents on Drug Delivery & Formulation Oxidative Stress and its Clinical Consequences: Relationship between Diabetes and Cancer
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Profilin1 Sensitizes Pancreatic Cancer Cells to Irradiation by Inducing Apoptosis and Reducing Autophagy
Current Molecular Medicine