Abstract
The aim of this paper is to review the antimicrobial activity of thiourea derivatives against planktonic and adherent bacterial and fungal strains, as well as to show how nanotechnology could improve the intrinsic antimicrobial activity of the novel substances, by obtaining biocompatible nanocomposites based on magnetite nanoparticles and newly synthesized 2-((4-ethylphenoxy)methyl)-N- (alkylphenylcarbamothioyl) benzamides, which proved increased resistance to microbial colonization or inhibited the development of already existent biofilms, revealing a great potential for biomedical applications.
Keywords: Benzamides, Thiourea derivatives, Magnetic nanoparticles, Anti-biofilm properties, Quorum sensing inhibitors
Current Organic Chemistry
Title:Antimicrobial Potential of Benzamides and Derived Nanosystems for Controlling in vitro Biofilm Development on Medical Devices
Volume: 17 Issue: 2
Author(s): Carmen Limban, Alexandru Mihai Grumezescu, Mariana Chirea, Lilia Matei and Mariana Carmen Chifiriuc
Affiliation:
Keywords: Benzamides, Thiourea derivatives, Magnetic nanoparticles, Anti-biofilm properties, Quorum sensing inhibitors
Abstract: The aim of this paper is to review the antimicrobial activity of thiourea derivatives against planktonic and adherent bacterial and fungal strains, as well as to show how nanotechnology could improve the intrinsic antimicrobial activity of the novel substances, by obtaining biocompatible nanocomposites based on magnetite nanoparticles and newly synthesized 2-((4-ethylphenoxy)methyl)-N- (alkylphenylcarbamothioyl) benzamides, which proved increased resistance to microbial colonization or inhibited the development of already existent biofilms, revealing a great potential for biomedical applications.
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Cite this article as:
Limban Carmen, Mihai Grumezescu Alexandru, Chirea Mariana, Matei Lilia and Carmen Chifiriuc Mariana, Antimicrobial Potential of Benzamides and Derived Nanosystems for Controlling in vitro Biofilm Development on Medical Devices, Current Organic Chemistry 2013; 17 (2) . https://dx.doi.org/10.2174/1385272811317020013
DOI https://dx.doi.org/10.2174/1385272811317020013 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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