Abstract
Proteins carry out many vital cellular functions determined by their precise 3-dimensional structures (the native conformations). Understanding how proteins fold has long been a major goal and can be of great therapeutic value. Failure to reach or maintain the correct folded structure can have serious consequences, as in the conformational diseases. The ultimate goal of folding studies is to predict structure from sequence, allowing the design of new functional proteins and prevention of aberrant disease-associated conformations.
Keywords: protein folding, misfolding, aggregation, amyloid, amyloidoses
Protein & Peptide Letters
Title: Protein Folding, Misfolding and Aggregation: Evolving Concepts and Conformational Diseases
Volume: 12 Issue: 3
Author(s): Carlos H.I. Ramos and Sergio T. Ferreira
Affiliation:
Keywords: protein folding, misfolding, aggregation, amyloid, amyloidoses
Abstract: Proteins carry out many vital cellular functions determined by their precise 3-dimensional structures (the native conformations). Understanding how proteins fold has long been a major goal and can be of great therapeutic value. Failure to reach or maintain the correct folded structure can have serious consequences, as in the conformational diseases. The ultimate goal of folding studies is to predict structure from sequence, allowing the design of new functional proteins and prevention of aberrant disease-associated conformations.
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Cite this article as:
Ramos H.I. Carlos and Ferreira T. Sergio, Protein Folding, Misfolding and Aggregation: Evolving Concepts and Conformational Diseases, Protein & Peptide Letters 2005; 12 (3) . https://dx.doi.org/10.2174/0929866053587156
DOI https://dx.doi.org/10.2174/0929866053587156 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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