Abstract
This study describes the synthesis of novel 4-nitro-2-substitutedimidazole derivatives via a transposition reaction of nitro group. Conversion of 5-nitro-2-phenylethanol (styryl) imidazole derivatives into the corresponding 4- nitroisomers was achieved in good yields in nitrobenzene using a catalytic amount of methyl iodide. Spectroscopic study and single crystal X-ray structures are reported for five compounds to understand the conformational structures of these compounds.
Keywords: Transposition reaction, 4-nitroimidazole, 5-nitroimidazole, crystal structure.
Letters in Organic Chemistry
Title:Synthesis, Spectroscopic and Structural Studies of New 2-Substituted 4- Nitroimidazoles
Volume: 11 Issue: 3
Author(s): Hayette Alliouche, Abdelmalek Bouraiou, Sofiane Bouacida, Mebarek Bahnous, Thierry Roisnel and Ali Belfaitah
Affiliation:
Keywords: Transposition reaction, 4-nitroimidazole, 5-nitroimidazole, crystal structure.
Abstract: This study describes the synthesis of novel 4-nitro-2-substitutedimidazole derivatives via a transposition reaction of nitro group. Conversion of 5-nitro-2-phenylethanol (styryl) imidazole derivatives into the corresponding 4- nitroisomers was achieved in good yields in nitrobenzene using a catalytic amount of methyl iodide. Spectroscopic study and single crystal X-ray structures are reported for five compounds to understand the conformational structures of these compounds.
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Cite this article as:
Alliouche Hayette, Bouraiou Abdelmalek, Bouacida Sofiane, Bahnous Mebarek, Roisnel Thierry and Belfaitah Ali, Synthesis, Spectroscopic and Structural Studies of New 2-Substituted 4- Nitroimidazoles, Letters in Organic Chemistry 2014; 11 (3) . https://dx.doi.org/10.2174/15701786113106660090
DOI https://dx.doi.org/10.2174/15701786113106660090 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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