Abstract
The design of selective COX-2 inhibitors is a new approach to obtain potent, anti-inflammatory drugs but with less side effects. Several families of such inhibitors were reported in literature. In this review, the drug design processes used to understand their binding mode and the origin of selectivity of these compounds are described.
Keywords: cox-2 inhibitor, selectivity, molecular modelling, x-ray, drug design, cox binding site, molecular features
Mini-Reviews in Medicinal Chemistry
Title: Structural Approach for COX-2 Inhibition
Volume: 4 Issue: 6
Author(s): C. Michaux and C. Charlier
Affiliation:
Keywords: cox-2 inhibitor, selectivity, molecular modelling, x-ray, drug design, cox binding site, molecular features
Abstract: The design of selective COX-2 inhibitors is a new approach to obtain potent, anti-inflammatory drugs but with less side effects. Several families of such inhibitors were reported in literature. In this review, the drug design processes used to understand their binding mode and the origin of selectivity of these compounds are described.
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Cite this article as:
Michaux C. and Charlier C., Structural Approach for COX-2 Inhibition, Mini-Reviews in Medicinal Chemistry 2004; 4 (6) . https://dx.doi.org/10.2174/1389557043403756
DOI https://dx.doi.org/10.2174/1389557043403756 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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