Abstract
Properties of benzimidazole and its derivatives have been studied for over hundred years; special interest of researchers triggered by the fact that 5,6-dimethylbenzimidazole is a component of naturally occurring vitamin B12. Several antihelminthic, antacid and antibacterial drugs are known which have benzimidazole moiety as their essential constituent. Additionally, several bis- and trisbenzimidazole based systems are well-known for their interaction with DNA and interference with several DNA associated processes. This account gives an overview of the benzimidazole based systems and their relevance in medicinal chemistry.
Keywords: Antibacterial, DNA-alkylation, intercalation, major- and minor-groove, transcription factor, polymerase, helicase, topoisomerase
Current Medicinal Chemistry
Title: Medical Implications of Benzimidazole Derivatives as Drugs Designed for Targeting DNA and DNA Associated Processes
Volume: 15 Issue: 18
Author(s): Santanu Bhattacharya and Padmaparna Chaudhuri
Affiliation:
Keywords: Antibacterial, DNA-alkylation, intercalation, major- and minor-groove, transcription factor, polymerase, helicase, topoisomerase
Abstract: Properties of benzimidazole and its derivatives have been studied for over hundred years; special interest of researchers triggered by the fact that 5,6-dimethylbenzimidazole is a component of naturally occurring vitamin B12. Several antihelminthic, antacid and antibacterial drugs are known which have benzimidazole moiety as their essential constituent. Additionally, several bis- and trisbenzimidazole based systems are well-known for their interaction with DNA and interference with several DNA associated processes. This account gives an overview of the benzimidazole based systems and their relevance in medicinal chemistry.
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Cite this article as:
Bhattacharya Santanu and Chaudhuri Padmaparna, Medical Implications of Benzimidazole Derivatives as Drugs Designed for Targeting DNA and DNA Associated Processes, Current Medicinal Chemistry 2008; 15 (18) . https://dx.doi.org/10.2174/092986708785133013
DOI https://dx.doi.org/10.2174/092986708785133013 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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