Abstract
Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.
Keywords: cellular signaling, diseases, ptps, sar, inhibitors, therapeutics/drugs
Current Medicinal Chemistry
Title: Protein Tyrosine Phosphatases and their Inhibitors
Volume: 12 Issue: 1
Author(s): Purushottam M. Dewang, Nai-Mu Hsu, Shao-Zheng Peng and Wen-Ren Li
Affiliation:
Keywords: cellular signaling, diseases, ptps, sar, inhibitors, therapeutics/drugs
Abstract: Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.
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Cite this article as:
Dewang M. Purushottam, Hsu Nai-Mu, Peng Shao-Zheng and Li Wen-Ren, Protein Tyrosine Phosphatases and their Inhibitors, Current Medicinal Chemistry 2005; 12 (1) . https://dx.doi.org/10.2174/0929867053363504
DOI https://dx.doi.org/10.2174/0929867053363504 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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