Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin

Authors: Franz, Thomas; Ruggeberg, Sabrina; Horn, Peter; Li, Xinping; Vajkoczy, Peter

Source: Protein and Peptide Letters, Volume 15, Number 1, January 2008 , pp. 43-46(4)

Publisher: Bentham Science Publishers

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Abstract:

During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the γ-carboxylation of the Glu-42 (Gla- 42).

Keywords: γ-Carboxy-glutamate; cerebrospinal fluid; moyamoya disease; post-translational modification; human transthyretin; two-dimensional gel electrophoresis

Document Type: Research article

DOI: 10.2174/092986608783330297

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