It has been demonstrated that the hyperglycemic response due to epinephrine secretion in anoxemia depends markedly upon the type of anoxemia induced. CO-anoxemia, a special type of anemic anoxemia, induced a marked one, whereas hypoxic anoxemia of considerable O₂ lack provoked only a slight one. The absence of chemoreceptor stimulation in the former might be responsible for this difference, since after extirpation of carotid bodies a marked hyperglycemic response was also observed in the latter case. It was concluded that the epinephrine secretion in anoxemia is conditioned by the anoxemic hypotension which is prevented by chemoreceptor stimulation, rather than the anoxemia itself.