Vogt-Koyanagi-Harada Disease Associated with Influenza A Virus Infection

Nozomu Yoshino; Ai Kawamura; Akira Ishii; Katsuyuki Yoshida; Tamami Watanabe; Takeshi Yamashita; Takahiko Fukuchi; Fumihiko Toyoda; Akihiko Kakehashi; Hitoshi Sugawara

doi:10.2169/internalmedicine.9819-17

CASE REPORTS

Vogt-Koyanagi-Harada Disease Associated with Influenza A Virus Infection

Nozomu Yoshino, Ai Kawamura, Akira Ishii, Katsuyuki Yoshida, Tamami Watanabe, Takeshi Yamashita, Takahiko Fukuchi, Fumihiko Toyoda, Akihiko Kakehashi, Hitoshi Sugawara

Author information

Nozomu Yoshino
Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Japan
Ai Kawamura
Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Japan
Akira Ishii
Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Japan
Katsuyuki Yoshida
Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Japan
Tamami Watanabe
Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Japan
Takeshi Yamashita
Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Japan
Takahiko Fukuchi
Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Japan
Fumihiko Toyoda
Divisions of Ophthalmology, Department of Comprehensive Medicine 2, Saitama Medical Center, Jichi Medical University, Japan
Akihiko Kakehashi
Divisions of Ophthalmology, Department of Comprehensive Medicine 2, Saitama Medical Center, Jichi Medical University, Japan
Hitoshi Sugawara
Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Japan

Keywords: Vogt-Koyanagi-Harada disease, influenza A virus, meningitis, peramivir, corticosteroids therapy

JOURNAL OPEN ACCESS

2018 Volume 57 Issue 11 Pages 1661-1665

DOI https://doi.org/10.2169/internalmedicine.9819-17

Browse “Advance online publication” version

Details

Abstract

We herein report a case of a 31-year-old Japanese man who simultaneously had a positive influenza A virus antigen test result and Vogt-Koyanagi-Harada disease (VKHD), demonstrated by both diffuse multiple early hyperfluorescent points on fluorescein fundus photography and serous retinal detachments on optical coherence tomography. He had meningitis. It was difficult to determine whether the main cause of meningitis was influenza A or VKHD. After initial treatment with peramivir for influenza A and then methylprednisolone pulse with subsequent corticosteroid therapy for VKHD, his symptoms improved gradually. These findings suggest that influenza A virus infection contributes to the onset or exacerbation of VKHD.

Corresponding author

Register with J-STAGE for free!