Encapsulating Peritoneal Sclerosis in Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Systemic Sclerosis

Mayumi Matsuda; Kazuhiro Yokota; Takaya Ichimura; Sakon Sakai; Takashi Maruyama; Takuma Tsuzuki Wada; Yasuto Araki; Yu Funakubo Asanuma; Yuji Akiyama; Atsushi Sasaki; Toshihide Mimura

doi:10.2169/internalmedicine.9793-22

CASE REPORTS

Encapsulating Peritoneal Sclerosis in Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Systemic Sclerosis

Mayumi Matsuda, Kazuhiro Yokota, Takaya Ichimura, Sakon Sakai, Takashi Maruyama, Takuma Tsuzuki Wada, Yasuto Araki, Yu Funakubo Asanuma, Yuji Akiyama, Atsushi Sasaki, Toshihide Mimura

Author information

Mayumi Matsuda
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Kazuhiro Yokota
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Takaya Ichimura
Department of Pathology, Faculty of Medicine, Saitama Medical University, Japan
Sakon Sakai
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Takashi Maruyama
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Takuma Tsuzuki Wada
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Yasuto Araki
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Yu Funakubo Asanuma
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Yuji Akiyama
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Division of Rheumatology, Department of Internal Medicine, Ogawa Red Cross Hospital, Japan
Atsushi Sasaki
Department of Pathology, Faculty of Medicine, Saitama Medical University, Japan
Toshihide Mimura
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan

Keywords: encapsulating peritoneal sclerosis, systemic lupus erythematosus, rheumatoid arthritis, tocilizumab, podoplanin

JOURNAL OPEN ACCESS

2023 Volume 62 Issue 11 Pages 1683-1689

DOI https://doi.org/10.2169/internalmedicine.9793-22

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Abstract

We encountered a 57-year-old Japanese woman with encapsulating peritoneal sclerosis (EPS) in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis. The patient was admitted to our hospital because of ascites retention. Administration of tocilizumab, an anti-interleukin-6 receptor antibody, for her RA reduced the refractory ascites remarkably; however, she developed sudden acute gastrointestinal bleeding and died a year later. On autopsy, sclerotic thickening of the peritoneum showed diffuse infiltration of podoplanin-positive fibroblast-like cells, and a diagnosis of EPS was made. EPS rarely occurs in SLE, and tocilizumab may be a new treatment candidate for EPS.

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