Non-uniform Progression of Chronic Tubulointerstitial Nephritis and Widespread Nephrocalcification in a Patient with Anorexia Nervosa

Sho Hasegawa; Maki Shibata; Makoto Mochizuki; Takashi Katsuki; Manami Tada; Fumihiko Hinoshita

doi:10.2169/internalmedicine.56.7594

CASE REPORTS

Non-uniform Progression of Chronic Tubulointerstitial Nephritis and Widespread Nephrocalcification in a Patient with Anorexia Nervosa

Sho Hasegawa, Maki Shibata, Makoto Mochizuki, Takashi Katsuki, Manami Tada, Fumihiko Hinoshita

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Keywords: anorexia nervosa, chronic tubulointerstitial nephritis, nephrocalcification, renal biopsy

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 5 Pages 545-549

DOI https://doi.org/10.2169/internalmedicine.56.7594

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Abstract

Although patients with anorexia nervosa (anorexia) are known to show tubulointerstitial nephritis (TIN), the pathophysiology of its progression is not fully understood. We herein report a 31-year-old woman with anorexia who showed acute exacerbation of chronic kidney disease. Renal biopsy showed non-uniform chronic TIN; some areas were obsolete lesions and other areas were active lesions. In addition, many calcium-containing crystals were widely deposited in the distal tubules. The results suggest that chronic TIN in the setting of anorexia does not uniformly progress and that not only TIN but also widespread calcification of distal tubules might aggravate the renal function of anorexia patients.

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