Rituximab-induced Acute Thrombocytopenia in High Tumor Burden Follicular Lymphoma

Hiroshi Ureshino; Atsujiro Nishioka; Kensuke Kojima; Motoaki Suzuki; Haruna Kizuka; Haruhiko Sano; Takero Shindo; Yasushi Kubota; Toshihiko Ando; Shinya Kimura

doi:10.2169/internalmedicine.55.6140

CASE REPORTS

Rituximab-induced Acute Thrombocytopenia in High Tumor Burden Follicular Lymphoma

Hiroshi Ureshino, Atsujiro Nishioka, Kensuke Kojima, Motoaki Suzuki, Haruna Kizuka, Haruhiko Sano, Takero Shindo, Yasushi Kubota, Toshihiko Ando, Shinya Kimura

Author information

Hiroshi Ureshino
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Atsujiro Nishioka
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Kensuke Kojima
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Motoaki Suzuki
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Haruna Kizuka
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Haruhiko Sano
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Takero Shindo
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Yasushi Kubota
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Toshihiko Ando
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
Shinya Kimura
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan

Keywords: rituximab, thrombocytopenia, follicular lymphoma

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 15 Pages 2061-2064

DOI https://doi.org/10.2169/internalmedicine.55.6140

Details

Abstract

Rituximab-induced acute thrombocytopenia (RIAT), a rare complication of rituximab administration, has not yet been described in follicular lymphoma (FL). A 65-year-old man received rituximab for the treatment of high tumor burden follicular lymphoma in the leukemic phase. The next day, his platelet count abruptly dropped from 85,000 to 5,000/μL, which spontaneously recovered in a few days without specific treatment. We speculate that the occurrence of infusion-related cytokine release syndrome in rituximab-sensitive high tumor burden FL contributed to the development of RIAT. Frequent monitoring of the platelet count is advisable for select patients considered to be at a high risk for RIAT.

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