Successful Treatment with Carboplatin and Pemetrexed for Multiple Lymph Node Metastases of Lymphoepithelioma-like Carcinoma from an Unknown Primary Site

Yuichiro Yasuda; Kazunori Tobino; Yuki Ko; Mina Asaji; Yoshikazu Yamaji; Kosuke Tsuruno; Hiroyuki Miyajima; Yosuke Mukasa; Noriyuki Ebi

doi:10.2169/internalmedicine.54.5020

CASE REPORTS

Successful Treatment with Carboplatin and Pemetrexed for Multiple Lymph Node Metastases of Lymphoepithelioma-like Carcinoma from an Unknown Primary Site

Yuichiro Yasuda, Kazunori Tobino, Yuki Ko, Mina Asaji, Yoshikazu Yamaji, Kosuke Tsuruno, Hiroyuki Miyajima, Yosuke Mukasa, Noriyuki Ebi

Author information

Yuichiro Yasuda
Department of Respiratory Medicine, Iizuka Hospital, Japan
Kazunori Tobino
Department of Respiratory Medicine, Iizuka Hospital, Japan
Department of Respiratory Medicine, Juntendo University, School of Medicine, Japan
Yuki Ko
Department of Respiratory Medicine, Iizuka Hospital, Japan
Mina Asaji
Department of Respiratory Medicine, Iizuka Hospital, Japan
Yoshikazu Yamaji
Department of Respiratory Medicine, Iizuka Hospital, Japan
Kosuke Tsuruno
Department of Respiratory Medicine, Iizuka Hospital, Japan
Hiroyuki Miyajima
Department of Respiratory Medicine, Iizuka Hospital, Japan
Yosuke Mukasa
Department of Respiratory Medicine, Iizuka Hospital, Japan
Noriyuki Ebi
Department of Respiratory Medicine, Iizuka Hospital, Japan

Keywords: lymphoepithelioma-like carcinoma, cancer of unknown origin, carboplatin, pemetrexed

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 20 Pages 2651-2654

DOI https://doi.org/10.2169/internalmedicine.54.5020

Details

Abstract

We herein report the case of an 80-year-old Japanese man with multiple lymph node metastases of lymphoepithelioma-like carcinoma (LELC) from an unknown primary site. The patient was admitted to our hospital due to hoarseness and left supraclavicular lymphadenopathy. Contrast-enhanced whole-body computed tomography revealed mediastinal, left supraclavicular, and left axillary lymphadenopathy. A left supraclavicular lymph node biopsy was performed and the specimen was consequently diagnosed as exhibting LELC. The patient's Eastern Cooperative Oncology Group performance status was 0, therefore he was started on chemotherapy with carboplatin and pemetrexed. His lymph nodes responded well to four cycles of chemotherapy without any intolerable adverse effect.

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