Improvement of Congestive Heart Failure after Octreotide and Transsphenoidal Surgery in a Patient with Acromegaly

Itaru Akaza; Kyoichiro Tsuchiya; Miho Akaza; Toru Sugiyama; Hajime Izumiyama; Masaru Doi; Takanobu Yoshimoto; Yukio Hirata

doi:10.2169/internalmedicine.48.1537

CASE REPORTS

Improvement of Congestive Heart Failure after Octreotide and Transsphenoidal Surgery in a Patient with Acromegaly

Itaru Akaza, Kyoichiro Tsuchiya, Miho Akaza, Toru Sugiyama, Hajime Izumiyama, Masaru Doi, Takanobu Yoshimoto, Yukio Hirata

Author information

Itaru Akaza
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
Kyoichiro Tsuchiya
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
Miho Akaza
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
Toru Sugiyama
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
Hajime Izumiyama
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
Masaru Doi
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
Takanobu Yoshimoto
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
Yukio Hirata
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School

Keywords: acromegaly, GH, IGF-1, pituitary tumor, octreotide, cardiomyopathy

JOURNAL OPEN ACCESS

2009 Volume 48 Issue 9 Pages 697-700

DOI https://doi.org/10.2169/internalmedicine.48.1537

Details

Abstract

A 59-year-old man was admitted because of congestive heart failure. He was suspected to have acromegaly, and magnetic resonance imaging revealed a pituitary macroadenoma. Endocrine examination revealed elevated plasma levels of growth hormone (GH) and insulin-like growth factor (IGF)-1, and an oral glucose tolerance test failed to suppress plasma GH levels, consistent with the diagnosis of GH-producing pituitary tumor. Treatment with octreotide, followed by transsphenoidal surgery resulted in normalization of plasma GH/IGF-1 levels, accompanied by the improvement of cardiac function. Thus, it is suggested that excess GH/IGF-1 axis is involved in the development of acromegaly-related cardiomyopathy in the present case.

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