Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Beneficial Effects of Pioglitazone on Cholangiohepatitis Induced by Bile Duct Carcinoma
Satoru SuzukiJun-ichirou MoriMasanori YamazakiAi SatoWaki HosodaKiyoshi Hashizume
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JOURNAL OPEN ACCESS

2007 Volume 46 Issue 20 Pages 1723-1728

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Abstract

Cholangiocarcinoma is a predominantly fatal cancer, which can be difficult to treat. We report a 73-year-old man who developed cholangiocarcinoma with cholangiohepatitis and diabetes. Administration of pioglitazone, peroxisome proliferator-activated receptor γ (PPARγ). agonist, improved not only diabetic control, but also the tumor-induced cholangiohepatitis, and improved the patient's quality of life. Although he finally died of obstructive jaundice, thiazolidinedione should be considered for treatment of tumor-induced hepatitis in the presence of diabetes, unless severe side effects occur.

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© 2007 by The Japanese Society of Internal Medicine
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