Pancreatic Neuroendocrine Neoplasm Invading the Entire Main Pancreatic Duct Diagnosed by a Preoperative Endoscopic Biopsy

Tomoya Kimura; Mitsuru Sugimoto; Tadayuki Takagi; Rei Suzuki; Naoki Konno; Hiroyuki Asama; Yuki Sato; Hiroki Irie; Jun Nakamura; Mika Takasumi; Minami Hashimoto; Tsunetaka Kato; Yasuhide Kofunato; Takashi Kimura; Shoki Yamada; Yuko Hashimoto; Shigeru Marubashi; Takuto Hikichi; Hiromasa Ohira

doi:10.2169/internalmedicine.4546-20

CASE REPORTS

Pancreatic Neuroendocrine Neoplasm Invading the Entire Main Pancreatic Duct Diagnosed by a Preoperative Endoscopic Biopsy

Tomoya Kimura, Mitsuru Sugimoto, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Yasuhide Kofunato, Takashi Kimura, Shoki Yamada, Yuko Hashimoto, Shigeru Marubashi, Takuto Hikichi, Hiromasa Ohira

Author information

Tomoya Kimura
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Mitsuru Sugimoto
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Tadayuki Takagi
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Rei Suzuki
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Naoki Konno
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Hiroyuki Asama
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Yuki Sato
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Hiroki Irie
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Jun Nakamura
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Department of Endoscopy, Fukushima Medical University Hospital, Japan
Mika Takasumi
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Minami Hashimoto
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Department of Endoscopy, Fukushima Medical University Hospital, Japan
Tsunetaka Kato
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan
Yasuhide Kofunato
Department of Hepato-Biliary-Pancreatic and Transplant Surgery, School of Medicine, Fukushima Medical University, Japan
Takashi Kimura
Department of Hepato-Biliary-Pancreatic and Transplant Surgery, School of Medicine, Fukushima Medical University, Japan
Shoki Yamada
Department of Diagnostic Pathology, School of Medicine, Fukushima Medical University, Japan
Yuko Hashimoto
Department of Diagnostic Pathology, School of Medicine, Fukushima Medical University, Japan
Shigeru Marubashi
Department of Hepato-Biliary-Pancreatic and Transplant Surgery, School of Medicine, Fukushima Medical University, Japan
Takuto Hikichi
Department of Endoscopy, Fukushima Medical University Hospital, Japan
Hiromasa Ohira
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Japan

Keywords: pancreatic neuroendocrine tumor, main pancreatic duct

JOURNAL OPEN ACCESS

2020 Volume 59 Issue 16 Pages 1991-1996

DOI https://doi.org/10.2169/internalmedicine.4546-20

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Abstract

A 78-year-old man was referred to our hospital for a detailed examination of a pancreatic tumor that filled the main pancreatic duct (MPD). The histological diagnosis of the endoscopic biopsy specimen was neuroendocrine tumor (NET) G3. The patient subsequently underwent total pancreatectomy. The histological diagnosis of the surgical specimen was also NET G3. This is the first report of a NET that occupied the MPD and was diagnosed by a preoperative endoscopic biopsy through the papilla of Vater. This case is a good example of a histopathological diagnostic method for pancreatic tumors invading the entire MPD.

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