Cowden's Disease Diagnosed through Mucocutaneous Lesions and Gastrointestinal Polyposis with Recurrent Hematochezia, Unrevealed by Initial Diagnosis

Masako KATO; Akira MIZUKI; Tatsuhiko HAYASHI; Takamu KUNIHIRO; Hiroshi NAGATA; Nobuhiro TSUKADA; Hideki ORIKASA; Shojiroh MORINAGA

doi:10.2169/internalmedicine.39.559

Masako KATO, Akira MIZUKI, Tatsuhiko HAYASHI, Takamu KUNIHIRO, Hiroshi NAGATA, Nobuhiro TSUKADA, Hideki ORIKASA, Shojiroh MORINAGA

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Keywords: multiple hamartoma syndrome, thyroid tumor, liver hemangioma

JOURNAL FREE ACCESS

2000 Volume 39 Issue 7 Pages 559-563

DOI https://doi.org/10.2169/internalmedicine.39.559

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Abstract

A 51-year-old man was admitted to our hospital because of hematochezia and painful keratotic plaques involving both hands. He had gastrointestinal polyposis, and a history of liver hemangiomas and thyroid tumor. Numerous papules on the face and papillomatosis on the oral mucosa were present. A diagnosis was made as a typical case of Cowden's disease according to the criteria proposed by Salem and Steck (J Am Acad Dermatol 8: 686, 1983). The patient was not correctly diagnosed initially in spite of typical manifestations of Cowden's disease, mainly due to his concomitant manifestations which occurred chronologically.
(Internal Medicine 39: 559-563, 2000)

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