The Sera from GM1 Ganglioside Antibody Positive Patients with Guillain-Barré Syndrome or Chronic Inflammatory Demyelinating Polyneuropathy Blocks Na+ Currents in Rat Single Myelinated Nerve Fibers

Tomoko TAKIGAWA; Hitoshi YASUDA; Masahiko TERADA; Masakazu HANEDA; Atsunori KASHIWAGI; Toyokazu SAITO; Takahiko SAIDA; Hiroshi KITASATO; Ryuichi KIKKAWA

doi:10.2169/internalmedicine.39.123

The Sera from GM1 Ganglioside Antibody Positive Patients with Guillain-Barré Syndrome or Chronic Inflammatory Demyelinating Polyneuropathy Blocks Na⁺ Currents in Rat Single Myelinated Nerve Fibers

Tomoko TAKIGAWA, Hitoshi YASUDA, Masahiko TERADA, Masakazu HANEDA, Atsunori KASHIWAGI, Toyokazu SAITO, Takahiko SAIDA, Hiroshi KITASATO, Ryuichi KIKKAWA

Author information

Tomoko TAKIGAWA
the Third Department of Medicine, Shiga University of Medical Science
Hitoshi YASUDA
the Third Department of Medicine, Shiga University of Medical Science
Masahiko TERADA
the Third Department of Medicine, Shiga University of Medical Science
Masakazu HANEDA
the Third Department of Medicine, Shiga University of Medical Science
Atsunori KASHIWAGI
the Third Department of Medicine, Shiga University of Medical Science
Toyokazu SAITO
the Department of Neurology, Kitasato University East Hospital
Takahiko SAIDA
Utano National Hospital
Hiroshi KITASATO
the Department of Physiology, Shiga University of Medical Science
Ryuichi KIKKAWA
the Third Department of Medicine, Shiga University of Medical Science

Keywords: anti-GM1 antibody, inflammatory polyneuropathy, ionic currents, voltage clamp, single fiber

JOURNAL FREE ACCESS

2000 Volume 39 Issue 2 Pages 123-127

DOI https://doi.org/10.2169/internalmedicine.39.123

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Abstract

Objective To determine the possible role of anti-GM1 ganglioside antisera from patients with Gullain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP) in the development of nerve dysfunction.
Methods The effect of the anti-GM1 antibody positive antisera obtained from 4 GBS patients and 1 CIDP patient on membrane potential and ionic currents in rat single myelinated nerve fibers was investigated using the voltage clamp technique and compared with that of the anti-GM1 negative antisera obtained from 3 healthy controls and 2 GBS patients.
Results In the presence of active complement, anti-GM1 positive antisera from 5 patients including 4 GBS patients and 1 CIDP patient significantly suppressed Na* current more than anti-GM1 negative antisera.
Conclusion This study supports the notion that anti-GM1 antibody is one of the causative factors of conduction abnormality in GBS patients.
(Internal Medicine 39: 123-127, 2000)

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