Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome Associated with Primary Anti-Phospholipid Antibody Syndrome
Kazuyoshi NAGAYAMA, Namiki IZUMI, Yuka MIYASAKA, Kazunori SAITO, Kei-ichi ONO, Osamu NOGUCHI, Yuji HOSHINO, Masakatsu UCHIHARA, Shozo MIYAKE, Nobuyuki ENOMOTO, Yujiro TANAKA, Fumiaki MARUMO, Chifumi SATO
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Keywords: abortion, liver dysfunction, microangiopathic hemolytic anemia, plasma exchange, pregnancy, thrombocytopenia
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1997 Volume 36 Issue 9 Pages 661-666

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Abstract

A 28-year-old woman with a history of a spontaneous abortion developed thrombocytopenia, Coombs-negative hemolytic anemia, and liver dysfunction at the sixteenth week of pregnancy. These findings were compatible with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome (hemolysis, elevated liver enzymes, and low platelet counts). Moreover, serum antiphospholipid antibodies were positive, suggesting the association of anti-phospholipid antibody syndrome. An artificial abortion, anti-coagulation therapy, and plasma exchange were performed concomitantly with corticosteroid therapy. She responded to the therapy, a remission was obtained. Anti-phospholipid antibodies may play a role in the pathogenesis of HELLP syndrome.
(Internal Medicine 36: 661-666, 1997)

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