Plasma Levels of Brain Natriuretic Peptide as an Index for Evaluation of Cardiac Function in Female Gene Carriers of Duchenne Muscular Dystrophy

Katsuhito ADACHI; Hisaomi KAWAI; Miho SAITO; Takako NARUO; Chiyomi KIMURA; Hideki MINE; Toshio INUI; Setsuko KASHIWAGI; Masashi AKAIKE

doi:10.2169/internalmedicine.36.497

Katsuhito ADACHI, Hisaomi KAWAI, Miho SAITO, Takako NARUO, Chiyomi KIMURA, Hideki MINE, Toshio INUI, Setsuko KASHIWAGI, Masashi AKAIKE

Author information

Katsuhito ADACHI
The Departments of Internal Medicine, National Sanatorium Tokushima Hospital
Hisaomi KAWAI
the First Department of Internal Medicine, School of Medicine, The University of Tokushima
Miho SAITO
The Departments of Internal Medicine, National Sanatorium Tokushima Hospital
Takako NARUO
The Departments of Internal Medicine, National Sanatorium Tokushima Hospital
Chiyomi KIMURA
The Departments of Internal Medicine, National Sanatorium Tokushima Hospital
Hideki MINE
The Departments of Internal Medicine, National Sanatorium Tokushima Hospital
Toshio INUI
The Departments of Neurology, National Sanatorium Tokushima Hospital
Setsuko KASHIWAGI
the First Department of Internal Medicine, School of Medicine, The University of Tokushima
Masashi AKAIKE
the First Department of Internal Medicine, School of Medicine, The University of Tokushima

Keywords: Duchenne muscular dystrophy (DMD), female gene carrier, brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), cardiac failure

JOURNAL FREE ACCESS

1997 Volume 36 Issue 7 Pages 497-500

DOI https://doi.org/10.2169/internalmedicine.36.497

Details

Abstract

The level of plasma brain natriuretic peptide (BNP) was elevated in 8 of 15 female gene carriers of Duchenne muscular dystrophy (DMD), and the level correlated with indices of cardiac function. In one of these carriers, whose clinical course was followed for one year, the plasma BNP level was elevated before the development of cardiac symptoms, further increased with the evolution of cardiac symptoms, and then decreased after treatment for cardiac failure. These results suggest that the plasma BNP level may be useful for the early detection of cardiac dysfunction and for evaluating the efficacy of cardiac treatment in female DMD carriers.
(Internal Medicine 36: 497-500, 1997)

Corresponding author

Register with J-STAGE for free!