Goodpasture's Syndrome : A Report of an Autopsy Case and a Review of Japanese Cases

Hideki WAKUI; Akihiko CHUBACHI; Kenichi ASAKURA; Shigeki NISHIMURA; Yasushi NAKAMOTO; Akira B MIURA

doi:10.2169/internalmedicine.31.102

Hideki WAKUI, Akihiko CHUBACHI, Kenichi ASAKURA, Shigeki NISHIMURA, Yasushi NAKAMOTO, Akira B MIURA

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Keywords: anti-glomerular basement membrane antibody, crescentic glomerulonephritis, pulmonary hemorrhage

JOURNAL FREE ACCESS

1992 Volume 31 Issue 1 Pages 102-107

DOI https://doi.org/10.2169/internalmedicine.31.102

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Abstract

A 75-yr-old man was admitted because of acute renal failure. On the 9th hospital day, pulmonary hemorrhage occurred. He was treated with a bolus dose of methylprednisolone and plasma exchange, but died from respiratory failure on the 16th hospital day. Autopsy findings demonstrated marked intraalveolar hemorrhage and crescentic glomerulonephritis. Linear depositions of IgG along both alveolar and glomerular basement membranes (GBM) were shown by direct immunofluorescent studies. Circulating anti-GBM antibodies were demonstrated by indirect immunofluorescent techniques. This is a confirmatory case of Goodpasture's syndrome, which is rare in Japan. A review of the Japanese literature revealed some characteristics of Japanese cases.
(Internal Medicine 31 : 102-107, 1992)

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