Colitis with Hypereosinophilia following the Second Dose of the BNT162b2 mRNA COVID-19 Vaccine: A Case Report with a Literature Review

Tsuyoshi Doman; Hiroaki Saito; Yukari Tanaka; Dai Hirasawa; Mareyuki Endo; Daichi Togo; Tomoki Matsuda

doi:10.2169/internalmedicine.0518-22

CASE REPORTS

Colitis with Hypereosinophilia following the Second Dose of the BNT162b2 mRNA COVID-19 Vaccine: A Case Report with a Literature Review

Tsuyoshi Doman, Hiroaki Saito, Yukari Tanaka, Dai Hirasawa, Mareyuki Endo, Daichi Togo, Tomoki Matsuda

Author information

Keywords: COVID-19, mRNA, vaccine, diarrhea, hypereosinophilia

JOURNAL OPEN ACCESS

2023 Volume 62 Issue 6 Pages 865-869

DOI https://doi.org/10.2169/internalmedicine.0518-22

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Abstract

A 61-year-old man presented with a 7-day history of watery diarrhea and loss of appetite after receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine. Laboratory studies showed significant eosinophilia and an elevated IgE level (white cell count, 18.4×10⁹/L; eosinophil count, 9.5×10⁹/L; and IgE level, 540 IU/L). Symptoms resolved 10 days after vaccination without any steroids or antiallergic medications, and the eosinophil count had also returned to within normal limits 2 months later. Several cases of eosinophilic disorders following receipt of any type of injectable COVID-19 vaccine have been reported, so the etiology should be examined.

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