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Capsaicin

A Promising Multifaceted Drug from Capsicum spp.

  • Review Article
  • Published:
Evidence-Based Integrative Medicine

Abstract

Capsaicin, the pungency-imparting alkaloid, is found only in the Capsicum genus. Capsaicin biosynthesis involves the phenyl propanoid and valine pathways and a final condensation step to involve vanillylamine and 8-methyl nonenoic acid catalysed by capsaicin synthase.

In recent times, capsaicin has been one of the most highly exploited biomolecules because of its versatility in application. So far, researchers have reported capsaicin as an antioxidant, antiarthritic, gastroprotective agent, anticancer (also procancer) agent and an analgesic. This review is a compilation of reports on the biosynthesis of capsaicin in Capsicum spp., the exploitation of capsaicin in pharmacy and the molecular mechanisms involved in capsaicin receptors.

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Table I

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Notes

  1. The use of trade names is for product identification purposes only and does not imply endorsement.

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Acknowledgements

This work was supported by a competitive grant to GAR during 2002–5 from the Department of Biotechnology, Ministry of Science and Technology, Government of India. BCNP and RS thank the Council of Scientific and Industrial Research and the Indian Council of Medical Research, New Delhi, for research fellowships. The authors have no conflicts of interest that are directly relevant to the content of this review.

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  1. Plant Cell Biotechnology Department, Central Food Technological Research Institute, Mysore, 570020, India

    B. C. N. Prasad, Richa Shrivastava &  Gokare A. Ravishankar (Scientist F and Head)

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Prasad, B.C.N., Shrivastava, R. & Ravishankar, G.A. Capsaicin. Evid-Based-Integrative-Med 2, 147–166 (2005). https://doi.org/10.2165/01197065-200502030-00006

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