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Chronic Low Dose Growth Hormone Treatment Stimulates Both Hypertrophy and Hyperplasia of Remnant Kidneys in Uraemic Rats

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Conclusion

In conclusion, low doses of exogenous rhGH, when administered in a manner similar to clinical practice, are associated with glomerular enlargement and stimulation of hypertrophy and hyperplasia of remnant kidneys from uraemic rats. Increased GV was also seen after short term, high dose rhGH therapy in our previous study.[4] The time interval required before increased GV develops with low dose rhGH therapy and whether or not further rhGH exposure subsequently leads to worsening glomerular hypertrophy, glomerulosclerosis[7] and renal failure cannot be determined from the current study. Although we observed no significant changes in renal function with rhGH therapy, we recommend that children with CRI be carefully monitored to ensure that long term rhGH treatment has no such deleterious effects.

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References

  1. Arnold WC, Danford D, Holliday M. Effects of caloric supplementation on growth in children with uremia. Kidney Int 1983; 24: 205–9

    Article  PubMed  CAS  Google Scholar 

  2. Mehls O, Ritz E. Skeletal growth in experimental uremia. Kidney Int 1983; 24: S53–S62

    Article  Google Scholar 

  3. Fine R, Kohaut EC, Brown D, et al. Growth after recombinant human growth hormone treatment in children with chronic renal failure: report of a multicenter randomized double-blind placebo-controlled study. J Pediatr 1994; 124: 374–82

    Article  PubMed  CAS  Google Scholar 

  4. Arnold WC, Shirkey B, Frindik P, et al. Effect of growth hormone on kidney growth and glomerular structure. Pediatr Nephrol 1991; 5: 529–32

    Article  PubMed  CAS  Google Scholar 

  5. Tonshoff B, Schaefer F, Mehls O. Disturbance of growth hormone-insulin like growth factor axis in uraemia. Implications for recombinant human growth hormone treatment. Pediatr Nephrol 1990; 4: 654–62

    Article  PubMed  CAS  Google Scholar 

  6. Allen DB, Fogo A, El-Hayek R, et al. Effects of prolonged growth hormone administration in rats with chronic renal insufficiency. Pediatr Res 1992; 31: 406–10

    Article  PubMed  CAS  Google Scholar 

  7. Doi T, Striker LJ, Quaife C, et al. Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulin-like growth factor-I. Am J Pathol 1988; 131: 398–403

    PubMed  CAS  Google Scholar 

  8. Labarca C, Paigen K. A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 1980; 102: 344–52

    Article  PubMed  CAS  Google Scholar 

  9. Hirose K, Osterby R, Nozawa M, et al. Development of glomerular lesions in experimental long-term diabetes in the rat. Kidney Int 1982; 21: 689–95

    Article  PubMed  CAS  Google Scholar 

  10. Dean AG, Dean JA, Coulombier D, et al. Epi Info, Version 6: a word processing, database, and statistics program for epidemiology on microcomputers. Centers for Disease Control and Prevention, Atlanta, Georgia, USA: 1994

    Google Scholar 

  11. Powell DR, Rosenfeld RG, Hintz RL. Effects of growth hormone therapy and malnutrition on the growth in rats with renal failure. Pediatr Nephrol 1988; 2: 424–30

    Article  Google Scholar 

  12. Santos F, Chan JCM, Hanna JD, et al. The effect of growth hormone on the growth failure of chronic renal failure. Pediatr Nephrol 1992; 6: 262–6

    Article  PubMed  CAS  Google Scholar 

  13. Nakano M, Kainer G, Foreman J, et al. The effects of exogenous rat growth hormone therapy on growth of uremic rats fed an 8% protein diet. Pediatr Res 1989; 26: 204–7

    Article  PubMed  CAS  Google Scholar 

  14. Mehls O, Irzynjec T, Ritz E, et al. Effects of rhGH and rhIGF-I on renal growth and morphology. Kidney Int 1993; 44: 1251–8

    Article  PubMed  CAS  Google Scholar 

  15. Stred SE, Benedict MR, Kuehnling E, et al. Effect of growth hormone on growth and glucose tolerance of normal rats. Am J Dis Child 1987; 141: 502–5

    PubMed  CAS  Google Scholar 

  16. Fine LG, Kurtz I, Woolf AS, et al. Pathophysiology and nephron adaptation in chronic renal failure. In: RW Schrier, CW Gottschalk, editors. Diseases of the kidney, 5th ed. Boston: Little, Brown and Co., 1993: 2703–41

    Google Scholar 

  17. Hirschberg R, Kopple JD. The growth hormone-insulin-like growth factor I axis and renal glomerular function. J Am Soc Nephrol 1992; 2: 1417–22

    PubMed  CAS  Google Scholar 

  18. Frindik JP, Kemp SF, Kearns GL. Epidermal growth factor concentrations in growth hormone deficient children. Effects of single versus multiple injections of recombinant human growth hormone. Drug Invest 1994; 8(5): 257–62

    Article  Google Scholar 

  19. Orlowski CC, Chernausek SD. Discordance of serum and tissue somatomedin levels in growth hormone-stimulated growth in the rat. Endocrinology 1988; 123: 44–9

    Article  PubMed  CAS  Google Scholar 

  20. Olsen S, Paulsen PS, Kirkegaard P, et al. Renal origin of urinary epithelial growth factor in the rat. Regul Pept 1984; 10: 37–47

    Article  CAS  Google Scholar 

  21. Perheentupa J, Lakshmanan J, Macaso T, et al. Growth hormone increases neonatal mouse urine epidermal growth factor. Acta Endocrinol 1984; 106: 184–7

    PubMed  CAS  Google Scholar 

  22. Ellis EN, Kemp SF, Frindik JP, et al. Glomerulopathy in patient with Donohue syndrome (Leprechaunism). Diabetes Care 1991; 14(5): 413–4

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    J. Paul Frindik & Eileen Ellis

  2. Department of Pediatric Nephrology, Cook-Fort Worth Children’s Medical Center, Fort Worth, Texas, USA

    Watson C. Arnold

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  1. J. Paul Frindik
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  2. Watson C. Arnold
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  3. Eileen Ellis
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Frindik, J.P., Arnold, W.C. & Ellis, E. Chronic Low Dose Growth Hormone Treatment Stimulates Both Hypertrophy and Hyperplasia of Remnant Kidneys in Uraemic Rats. Clin. Drug Invest. 10, 183–187 (1995). https://doi.org/10.2165/00044011-199510030-00008

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  • DOI: https://doi.org/10.2165/00044011-199510030-00008

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