Summary
The in vitro efficacy of temocillin in combination with ticarcillin and with gentamicin, tobramycin, amikacin and netilmicin against 80 Gram-negative and 20 Gram-positive bacterial strains was compared by use of the checkerboard agar dilution technique. No synergistic or additive effect was seen on the Gram-positive strains. Great variations occurred between the different bacterial species, and the temocillin-ticarcillin combination had only little effect against the Pseudomonas strains tested. On average, only 12% of all strains tested were inhibited synergistically by temocillin-gentamicin combinations, and only 7 to 10% by combinations of temocillin with the other aminoglycosides. However, 25% of Gram-negative strains were inhibited synergistically and 40% of Gram-negative strains were inhibited additively by the combination of temocillin-gentamicin.
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Just, HM., Becker, C., Gieringer, J. et al. In Vitro Combination-Effect of Temocillin with Ticarcillin and Aminoglycosides on Gram-Negative and Gram-Positive Bacteria. Drugs 29 (Suppl 5), 74–77 (1985). https://doi.org/10.2165/00003495-198500295-00015
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DOI: https://doi.org/10.2165/00003495-198500295-00015