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Clinical Pharmacokinetic Properties of the Macrolide Antibiotics

Effects of Age and Various Pathophysiological States (Part II)

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  • Drug Disposition
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References

  • Acar JF, Saint-Salvi B, Blanc F. Concentrations of roxithromycin in tear fluid and saliva after repeated dosing. British Journal of Clinical Practice 42 (Suppl. 55): 82, 1988

    Google Scholar 

  • Albin H, Vincon G, Pehourcq F, Dangoumau J. Influence de la josamycine sur la pharmacocinétique de la carbamazèpine. Thérapie 37: 151–157, 1982

    PubMed  CAS  Google Scholar 

  • Andrews JM, Ashby JP, Wise R. Factors affecting the in vitro activity of roxithromycin. Journal of Antimicrobial Chemotherapy 20 (Suppl. B): 31–38, 1987

    PubMed  CAS  Google Scholar 

  • Armstrong JR, Cook FE, Robinson JR. Concentration of antibiotic and chemotherapeutic agents in the ejaculum. Journal of Urology 100: 72–76, 1968

    PubMed  CAS  Google Scholar 

  • Aronoff SC, Laurent C, Jacobs MR. In vitro activity of erythromycin, roxithromycin and CP-62993 against common pediatric pathogens. Journal of Antimicrobial Chemotherapy 19: 275–276, 1987

    Article  PubMed  CAS  Google Scholar 

  • Auckenthaler RW, Zwahlen A, Waldvogel FA. Macrolides. In Peterson & Varholf (Eds) The antimicrobial agents annual/2, pp. 116–130, Elsevier, Amsterdam, 1987

    Google Scholar 

  • Austin KL, Mather LE, Philpot CR, McDonald PJ. Intersubject and dose-related variability after intravenous administration of erythromycin. British Journal of Clinical Pharmacology 10: 273–279, 1980

    Article  PubMed  CAS  Google Scholar 

  • Bachmann K, Schwartz JI, Forney Jr R, Frogameni A, Jauregui LE. The effect of erythromycin on the disposition kinetics of warfarin. Pharmacology 28: 171–176, 1984

    Article  PubMed  CAS  Google Scholar 

  • Barlam T, Neu HC. In vitro comparison of the activity of RU 28965, a new macrolide, with that of erythromycin against aerobic and anaerobic bacteria. Antimicrobial Agents and Chemotherapy 25: 529–531, 1984

    Article  PubMed  CAS  Google Scholar 

  • Bartle WR. Possible warfarin-erythromycin interaction. Archives of Internal Medicine 140: 985–987, 1980

    Article  PubMed  CAS  Google Scholar 

  • Bass JW, Steele RW, Wiebe RA, Dierdorft EP. Erythromycin concentration in middle ear exudate. Pediatrics 48: 417–422, 1971

    PubMed  CAS  Google Scholar 

  • Baumueller A, Hoyme U, Madsen PO. Rosaramicin — a new drug for the treatment of bacterial prostatitis. Antimicrobial Agents and Chemotherapy 12: 240–242, 1977

    Article  PubMed  CAS  Google Scholar 

  • Bégué P, Kafetsis DA, Albin H, Safran Ch. Pharmacokinetics of roxithromycin in paediatrics. Journal of Antimicrobial Chemotherapy 20 (Suppl. B): 101–106, 1987

    PubMed  Google Scholar 

  • Bégué P, Lacombe H, Cotin G, Chaviere F, Chrétien P, et al. Diffusion of roxithromycin into tonsillar tissue in children. British Journal of Clinical Practice 42 (Suppl. 55): 78–79, 1988

    Google Scholar 

  • Bergan T. Pharmacokinetics of tissue penetration of antibiotics. Reviews of Infectious Diseases 3: 45–66, 1981

    Article  PubMed  CAS  Google Scholar 

  • Bergan T, Engeset A, Olszewski W. Does serum protein binding inhibit tissue penetration of antibiotics? Reviews of Infectious Diseases 9: 713–718, 1987

    Article  PubMed  CAS  Google Scholar 

  • Bergan T, Engeset A, Olszewski W, Josefsson K, Larsen N. Penetration of erythromycin into human peripheral lymph. Journal of Antimicrobial Chemotherapy 10: 319–322, 1982

    Article  PubMed  CAS  Google Scholar 

  • Bergan T, Tolas P, Oydvin B. Influence of food and hepatobiliary disease on the excretion of josamycin. Pharmacology 8: 336–343, 1972

    Article  PubMed  CAS  Google Scholar 

  • Bergogne-Bérézin E. The tissue penetration of macrolides with particular reference to the respiratory tract. In Butzler & Kobayashi (Eds) Macrolides: a review with an outlook on future developments, pp. 43–53, Excerpta Medica, Amsterdam, 1986

    Google Scholar 

  • Bergogne-Bérézin E. Tissue distribution of roxithromycin. Journal of Antimicrobial Chemotherapy 20 (Suppl. B): 113–120, 1987

    PubMed  Google Scholar 

  • Bergogne-Bérézin E, Berthelot G, Uzzan J, Ravina JH. Evaluation of placental transfer of roxithromycin in late pregnancy. 27th Interscience Conference on Antimicrobial Agents and Chemotherapy, New York, 4–7 October 1987. Abstract No. 10977, p. 285, 1987

  • Bergogne-Bérézin E, Morel C, Even P, Bernard Y, Kafe H, et al. Pharmacocinétique des antibiotiques dans les voies respiratoires. Nouvelle Presse Médicale 7: 2831–2836, 1978

    PubMed  Google Scholar 

  • Bosco U. Utilità di una preparazione di eritromicina in supposte nella pratica pediatrica. Minerva Pediatrica 17: 401–402, 1973

    Google Scholar 

  • Botto H, Camay M, Chrétien P, Safran C. Study of the diffusion of roxithromycin into prostatic tissue after repeat oral dosing. British Journal of Clinical Practice 42 (Suppl. 55): 83, 1988

    Google Scholar 

  • Brazier JL, Kofman J, Faucon G, Perrin-Fayolle M, Lepape A, et al. Retard d’élimination de la théophylline dû à la troléandomycine. Absence d’effet de la josamycine. Thérapie 35: 545–549, 1980

    PubMed  CAS  Google Scholar 

  • Brittain DC. Update on antibiotics I. Erythromycin. Medical Clinics of North America 71: 1147–1154, 1987

    PubMed  CAS  Google Scholar 

  • Brun Y, Forey F, Gamondes JP, Tebib A, Brune J, et al. Levels of erythromycin in pulmonary tissue and bronchial mucus compared to those of amoxycillin. Journal of Antimicrobial Chemotherapy 8: 459–446, 1981

    Article  PubMed  CAS  Google Scholar 

  • Bryskier A, Chantot JF, Lasc JC. Classification and structure-activity relationships of macrolides with emphasis on new developments. In Butzler & Kobayashi (Eds) Macrolides: a review with an outlook on future developments, pp. 7–21, Excerpta Medica, Amsterdam, 1986

    Google Scholar 

  • Carlier MB, Zenebergh A, Tulkens PM. Cellular uptake and subcellular distribution of roxithromycin and erythromycin in phagocytic cells. Journal of Antimicrobial Chemotherapy 20 (Suppl. B): 47–56, 1987

    PubMed  CAS  Google Scholar 

  • Carlone NA, Ciuffini AM, Del Mastro S, Bonino S. Determinazione microbiologica dei livelli tonsillari ed oculari di josamicina in soggetti ospedalizzati. Giornale Italiano di Chemioterapia 29 (Suppl. 1): 77–83, 1982

    PubMed  Google Scholar 

  • Carlone NA, Ciuffini AM, Tullio V, Sassella D. Uptake of roxithromycin by mouse peritoneal macrophages. In Berkarda & Kuemmerle (Eds) Progress in chemotherapy. Proceedings of the 15th International Congress of Chemotherapy, Istanbul, 19–24 July 1987. Antimicrobial Section Vol. 1: pp. 506–508, Ecomed, Landsberg, 1987

    Google Scholar 

  • Chabbert Y. Etude in vitro sur la spiramycine. Annales de l’Institut Pasteur 89: 434–446, 1955

    PubMed  CAS  Google Scholar 

  • Chastre J, Brun P, Fourtillan JB, Soler P, Basset G, et al. Pulmonary disposition of roxithromycin (RU 28965), a new macrolide antibiotic. Antimicrobial Agents and Chemotherapy 31: 1312–1316, 1987

    Article  PubMed  CAS  Google Scholar 

  • Chelvan P, Hamilton-Miller JMT, Brumfitt W. Biliary excretion of erythromycin after parenteral administration. British Journal of Clinical Pharmacology 8: 233–235, 1979

    Article  PubMed  CAS  Google Scholar 

  • Chen ML, Chiou WL. Analysis of erythromycin in biological fluids by high-performance liquid chromatography with electrochemical detection. Journal of Chromatography 278: 91–100, 1983

    Article  PubMed  CAS  Google Scholar 

  • Chow AW. Erythromycin. In Ristuccia & Cunha (Eds) Antimicrobial therapy, pp. 209–218, Raven Press, New York, 1984

    Google Scholar 

  • Clauzel AM, Simeon de Buochberg M, Jars N, Michel FB. Etude du passage de la midécamycine dans les expectorations. Nouvelle Presse Médicale 10: 1658, 1981

    Google Scholar 

  • Concia E, Cruciani M, Barzaghi N, Bartucci F, Sassella D. Diffusion of roxithromycin into suction skin blister fluid. British Journal of Clinical Practice 42 (Suppl. 55): 86–87, 1988

    Google Scholar 

  • Coppi G, Alberti D. Thiopronine and lung levels of erythromycin. Journal of Antimicrobial Chemotherapy 14: 307–308, 1984

    Article  PubMed  CAS  Google Scholar 

  • Coyne TC, Shum S, Chun AHC, Jeansonne L, Shirkey HC. Bioavailability of erythromycin ethylsuccinate in pediatric patients. Journal of Clinical Pharmacology 18: 194–202, 1978

    PubMed  CAS  Google Scholar 

  • Cummings LH, Kozak PP, Gillman A. Erythromycin’s effect on theophylline blood levels. Pediatrics 59: 144–145, 1977

    Google Scholar 

  • Czinn S, Carr H, Aronoff S. Susceptibility of Campylobacter pyloridis to three macrolide antibiotics (erythromycin, roxithromycin [RU 28965], and CP-62,993) and rifampicin. Antimicrobial Agents and Chemotherapy 30: 328–329, 1986

    Article  PubMed  CAS  Google Scholar 

  • De Grandi P, Comte R, Van Moos G, Grutter F, Péchère JC. Concentrations of roxithromycin in plasma and gynaecological tissues following repeated oral administrations. British Journal of Clinical Practice 42 (Suppl. 55): 84–85, 1988

    Google Scholar 

  • Delaforge M, Jaouen M, Manguy D. Dual effects of macrolide antibiotics on rat liver cytochrome P-450. Induction and formation of metabolite-complexes: a structure-activity relationship. Biochemical Pharmacology 32: 2309–2318, 1983

    Article  PubMed  CAS  Google Scholar 

  • Delaforge M, Sartori E, Mansuy D. Effects of roxithromycin on rat hepatic P-450 cytochromes: comparison with troleandomycin and erythromycin. British Journal of Clinical Practice 42 (Suppl. 55): 67–69, 1988

    Google Scholar 

  • De Louvois J. Factors influencing the assay of antimicrobial drugs in clinical samples by the agar plate diffusion method. Journal of Antimicrobial Chemotherapy 9: 253, 1982

    Article  PubMed  Google Scholar 

  • Descotes J, André P, Evreux JC. Pharmacokinetic drug interactions with macrolide antibiotics. Journal of Antimicrobial Chemotherapy 15: 659–664, 1985a

    Article  PubMed  CAS  Google Scholar 

  • Descotes J, Ghanassia JP, Simonet R, Evreux JCL. Influence of josamycin on caffeine disposition in human healthy volunteers. In Ishigami (Ed.) Recent advances in chemotherapy. Proceedings of the 14th International Congress of Chemotherapy, Kyoto, 23–28 June 1985. Antimicrobial Section 2, pp. 1481–1482, University of Tokyo Press, Tokyo, 1985b

    Google Scholar 

  • Dette GA, Knothe H. Kinetics of erythromycin uptake and release by human lymphocytes and polymorphonuclear leucocytes. Journal of Antimicrobial Chemotherapy 18: 73–82, 1986

    Article  PubMed  CAS  Google Scholar 

  • Dette GA, Knothe H, Herrmann G. Kinetics of erythromycin binding to human serum. In Periti & Gialdroni Grassi (Eds) Current chemotherapy and immunotherapy. Proceedings of the 12th International Congress of Chemotherapy, Florence, 19–24 July 1981. Vol. II, pp. 911–912, American Society for Microbiology, Washington D.C., 1981

    Google Scholar 

  • Dette GA, Knothe H, Herrmann G. Erythromycin binding to human serum. Biochemical Pharmacology 31: 1081–1087, 1982

    Article  PubMed  CAS  Google Scholar 

  • Dewever M. Determination of roxithromycin concentrations in the mucosa of the maxillary sinus. British Journal of Clinical Practice 42 (Suppl. 55): 81, 1988

    Google Scholar 

  • Disanto AR, Chodos DJ. Influence of study design in assessing food effects on absorption of erythromycin base and erythromycin stearate. Antimicrobial Agents and Chemotherapy 20: 190–196, 1981

    Article  PubMed  CAS  Google Scholar 

  • Disanto AR, Tsering KY, Chodos DJ, DeSante DA, Albert KS, et al. Comparative bioavailability evaluation of erythromycin base and its salts and esters. I. Erythromycin estolate capsules versus enteric-coated erythromycin base tablets. Journal of Clinical Pharmacology 20: 437–443, 1980

    PubMed  CAS  Google Scholar 

  • Disse B, Gundert-Remy U, Weber E, Andrassy K, Stetzen W, et al. Pharmacokinetics of erythromycin in patients with different degrees of renal impairment. International Journal of Clinical Pharmacology, Therapy and Toxicology 24: 460–464, 1986

    CAS  Google Scholar 

  • Dow J, Lemar M, Frydman A, Gaillot J. Automated high-performance liquid chromatographic determination of spiramycin by direct injection of plasma, using column-switching for sample clean-up. Journal of Chromatography 344: 275–283, 1985

    Article  PubMed  CAS  Google Scholar 

  • Dravet C, Mesdjian E, Cenraud B, Roger J. Interaction carbamazépine-troléandomycine: une nouvelle interaction médicamenteuse? Nouvelle Press Médicale 6: 567–569, 1977

    Google Scholar 

  • Ducci M, Scalori V, del Tacca M, Soldani G, Bernardini C, et al. The pharmacokinetics of two erythromycin esters in plasma and in saliva following oral administration in humans. International Journal of Clinical Pharmacology, Therapy and Toxicology 19: 494–497, 1981

    CAS  Google Scholar 

  • Duthu GS. Interspecies correlation and the pharmacokinetics of erythromycin, oleandomycin, and tylosin. Journal of Pharmaceutical Sciences 74: 943–946, 1985

    Article  PubMed  CAS  Google Scholar 

  • Fagioli A, Cruciani E, Riario Sforza G, Ferrone G, Di Silverio F. Livelli tissutali prostatici di josamicina. Giornale Italiano di Chemioterapia 29 (Suppl. 1): 85–87, 1982

    PubMed  Google Scholar 

  • Falchi M, Teodori F, Carraro A, Cioce C, Scaglione F, et al. Penetration of erythromycin into tonsillar tissue. Current Medical Research and Opinion 9: 611–615, 1985

    Article  PubMed  CAS  Google Scholar 

  • Fiese EF, Steffen SH. Comparison of the acid stability of azithromycin (CP-62,993) and erythromycin A. 27th Interscience Conference on Antimicrobial Agents and Chemotherapy, New York, 4–7 October 1987. Abstract No. 229, p. 136, 1987

  • Fioretti M, Bandera M, Rimoldi R. Attività terapeutica e comportamento farmacocinetico della miocamicina a livello dell’apparato respiratorio. Giornale Italiano di Chemioterapia 31: 145–148, 1984

    PubMed  CAS  Google Scholar 

  • Fourtillan JB, Lefèbvre MA, Ghanassia JP. Pharmacokinetic handling of josamycin and its metabolites during oral repeated dosing in man. In Spitzy & Karrer (Eds) Proceedings of the 13th International Congress of Chemotherapy, Vienna, 1983. Vol. 5, pp. SS 4.4/1–2, 36/11–14, Egermann Druckereigesellschaft, 1983

  • Fourtillan JB, Lefèbvre MA, Gobin P. Josamycin chemical determination in biological fluids. Giornale Italiano di Chemioterapia 29 (Suppl. 1): 103–108, 1982

    PubMed  Google Scholar 

  • Fraschini F, Braga PC, Gagliardi V, Falchi M, Scaglione F, et al. Farmacocinetica della josamicina nell’uomo e distribuzione in vari compartimenti. Giornale Italiano di Chemioterapia 29 (Suppl. I): 69–76, 1982

    PubMed  Google Scholar 

  • Fraschini F, Scaglione F, Cantarella Marchi E, Scarpazza P, Falchi M, et al. Plasma and tissue concentrations of miocamycin in humans. In Ishigami (Ed.) Recent advances in chemotherapy. Proceedings of the 14th International Congress of Chemotherapy, 23–28 June 1985. Antimicrobial Section 2, pp. 1447–1449, University of Tokyo Press, Tokyo, 1985

    Google Scholar 

  • Fraser DG. Selection of oral erythromycin product. American Journal of Hospital Pharmacy 37: 1199–1205, 1980

    PubMed  CAS  Google Scholar 

  • Freeman DJ, Martell R, Carruthers SG, Keown PA, Stiller CR. Cyclosporin-erythromycin interaction in normal subjects. British Journal of Clinical Pharmacology 23: 776–778, 1987

    PubMed  CAS  Google Scholar 

  • Fukaya K, Shomura S, Kitai S, Murata S, Umemura K. Absorption, metabolism and excretion of 9,3″-diacetyl-midecamycin (MOM) in humans. Acta Toxicologica et Therapeutica 2: 45–64, 1981

    Google Scholar 

  • Fukaya K, Watanabe S, Fujita M. Absorption and excretion of miocamycin tablets and dry syrup. In Ishigami (Ed.) Recent advances in chemotherapy. Proceedings of the 14th International Congress of Chemotherapy, Kyoto, 23–28 June 1985. Antimicrobial Section 2, pp. 1450–1451, University of Tokyo Press, Tokyo, 1985

    Google Scholar 

  • Gaillot J, Lemar M. Eléments de pharmacocinétique de la spiramycine chez l’homme. Réunion interdisciplinaire Chimiothérapie antiinfective 3-12-1981, Vol. 43, p. 4, Paris, 1981

    Google Scholar 

  • Galioto GB, Ortisi G, Nevio E, Bartucci F, Privitera G. Concentrations of roxithromycin (RU 28965) in serum and tonsil after single and multiple doses. In Berkarda & Kuemmerle (Eds) Progress in chemotherapy. Proceedings of the 15th International Congress of Chemotherapy, Istanbul, 19–24 July 1987. Antimicrobial Section Vol. 1, pp 191–193, Ecomed, Landsberg 1987

    Google Scholar 

  • Garrod LP, Lambert HP, O’Grady F. Macrolides and lincosamides. In Fifth (Ed.) Antibiotic and chemotherapy, pp. 183–201, Churchill Livingstone, London, 1981

    Google Scholar 

  • Ghanassia JP, Modai J, Fourtillan JB. Pharmacokinetics of josamycin in young adults and geriatric patients. In Periti & Gialdroni Grassi (Eds) Current chemotherapy and immunotherapy. Proceedings of the 12th International Congress of Chemotherapy, Florence, 19–24 July 1981. Vol. II, pp. 89–90, American Society for Microbiology, Washington, 1985

    Google Scholar 

  • Gordon RC, Regamey C, Kirby WMM. Serum protein binding of erythromycin, lincomycin and clindamycin. Journal of Pharmaceutical Sciences 62: 1074–1077, 1973

    Article  PubMed  CAS  Google Scholar 

  • Gribble MJ, Chow AW. Erythromycin. Medical Clinics of North America 66: 79–89, 1982

    PubMed  CAS  Google Scholar 

  • Griffith RS, Black HR. Erythromycin. Medical Clinics of North America 54: 1199–1215, 1970

    PubMed  CAS  Google Scholar 

  • Grove D, Randall WA. Assay methods of antibiotics. Medical Encyclopedia, Inc., New York, 1955

    Google Scholar 

  • Hall KW, Nightingale CH, Gibaldi M, Nelson E, Bates TR, et al. Pharmacokinetics of erythromycin in normal and alcoholic liver disease subjects. Journal of Clinical Pharmacology 22: 321–325, 1982

    Article  PubMed  CAS  Google Scholar 

  • Hammond JB, Griffith RS. Factors affecting the absorption and biliary excretion of erythromycin and two of its derivatives in humans. Clinical Pharmacology and Therapeutics 2: 308–312, 1961

    PubMed  CAS  Google Scholar 

  • Hand LW, Boozer RM, King-Thompson NL. Antibiotic uptake by alveolar macrophages of smokers. Antimicrobial Agents and Chemotherapy 27: 42–45, 1985

    Article  PubMed  CAS  Google Scholar 

  • Hand WL, King-Thompson N, Holman JW. Entry of roxithromycin (RU 965), imipenem, cefotaxime, trimethoprim, and metronidazole into human polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy 31: 1553–1557, 1987

    Article  PubMed  CAS  Google Scholar 

  • Heimdahl A, Nord CE. Impact of erythromycin on the normal human flora and colonization of the oral cavity, throat, and colon. In Periti & Gialdroni Grassi (Eds) Current chemotherapy and immunotherapy. Proceedings of the 12th International Congress of Chemotherapy, Florence, 19–24 July 1981. Vol. II, pp. 914–916, American Society for Microbiology, Washington D.C., 1981

    Google Scholar 

  • Hemsworth TC, Renton KW. Depression of theophylline metabolism and elimination by troleandomycin and erythromycin. Biochemical Pharmacology 30: 1299–1304, 1981

    Article  PubMed  CAS  Google Scholar 

  • Hildebrandt R, Moller H, Gundert-Remy U. Influence of theophylline on the renal clearance of erythromycin. International Journal of Clinical Pharmacology, Therapy and Toxicology 25: 601–604, 1987

    CAS  Google Scholar 

  • Hovi T, Heikinheimo M. Effect of concomitant food intake on absorption kinetics of erythromycin in healthy volunteers. European Journal of Clinical Pharmcology 28: 231–233, 1985

    Article  CAS  Google Scholar 

  • Hoyme U, Baumueller A, Madsen PO. Antibiotics excreting in canine vaginal and urethral secretions. Investigative Urology 16: 35–38, 1978

    PubMed  CAS  Google Scholar 

  • Hudson D, Yoshihara G, Kirby W. Spiramycin. Archives of Internal Medicine 97: 57–61, 1956

    Article  PubMed  CAS  Google Scholar 

  • Ikeda C, Kikuchi Y, Matsui H, Tachibana A. Effects of food on bioavailability of josamycin and josamycin propionate. In Ishigami (Ed.) Recent advances in chemotherapy. Proceedings of the 14th International Congress of Chemotherapy, Kyoto, 23–28 June 1985. Antimicrobial Section 2, pp. 1483–1484, University of Tokyo Press, Tokyo, 1985

    Google Scholar 

  • Iliopolou A, Aldhous ME, Johnston A, Turner P. Pharmacokinetic interaction between theophylline and erythromycin. British Journal of Clinical Pharmacology 14: 495–499, 1982

    Article  Google Scholar 

  • Inouye S, Niida T. Discovery and development of midecamycin. In Periti & Gialdroni Grassi (Eds) Current chemotherapy and immunotherapy. Proceedings of the 12th International Congress of Chemotherapy, pp. 887–889, American Society for Microbiology, Washington D.C., 1981

    Google Scholar 

  • Iwasawa T. Basic and clinical assessments of midecamycin. Chemotherapy 21: 870–881, 1973

    Google Scholar 

  • Jiménez Baos R, Cadórniga Carro R, Moreno Ubeda M, Casado de Frias E. Effects of josamycin on serum levels of theophylline. In Spitzy & Karrer (Eds) Proceedings of the 13th International Congress of Chemotherapy, Vienna, 28 August–2 September, 1983. Vol. 5, pp. 36/61–36/65, Egermann Druckereigesellschaft, 1983

  • Jones RN, Barry AL, Thornsberry C. In vitro evaluation of three new macrolide antimicrobial agents, RU 28965, RU 29065 and RU 29702, and comparison with other orally administered drugs. Antimicrobial Agents and Chemotherapy 24: 209–215, 1983

    Article  PubMed  CAS  Google Scholar 

  • Josefsson K, Digranes A, Schreiner A. Influence of food on absorption of enteric-coated pellets of erythromycin base and of tablets of erythromycin stearate. In Spitzy & Karrer (Eds) Proceedings of the 13th International Congress of Chemotherapy, Vienna, 28 August–2 September 1983. Vol. 5, PS4.4/1–3, pp. 107/11–14, Egermann Druckereigesellschaft, 1983a

  • Josefsson K, Graffner C, Magni L. Reproducibility of erythromycin serum levels when given in enteric-coated pellets. In Spitzy & Karrer (Eds) Proceedings of the 13th International Congress of Chemotherapy, Vienna, 28 August–2 September 1983. Vol. 5, PS4.4/1–4, pp. 107/15–107/18, Egermann Druckereigesellschaft, 1983b

  • Josefsson K, Steinbakk M, Bergan T, Midtvedt T, Magni L. Pharmacokinetics of a new, microencapsulated erythromycin base after repeated oral doses. Chemotherapy 28: 176–184, 1982

    Article  PubMed  CAS  Google Scholar 

  • Josselyn LE, Sylvester JC. Absorption of erythromycin. Antibiotics and Chemotherapy 3: 63–69, 1953

    CAS  Google Scholar 

  • Kafetzis DA, Krotsi-Laskari M, Tremblay D, Saint-Salvi B. Multiple dose pharmacokinetics in infants and children treated with roxithromycin. British Journal of Clinical Practice 42 (Suppl. 55): 58, 1988a

    Google Scholar 

  • Kafetzis DA, Ligatsikas C, Saint-Salvi B, Lenfant B, Blanc F. Concentrations of roxithromycin in tonsil and adenoid tissues after single and repeated administrations to children. British Journal of Clinical Practice 42 (Suppl. 55): 80, 1988b

    Google Scholar 

  • Kamme C, Kahlmeter G, Melander A. Evaluation of spiramycin as a therapeutic agent for elimination of nasopharyngeal pathogens. Scandinavian Journal of Infectious Diseases 10: 135–142, 1978

    PubMed  CAS  Google Scholar 

  • Katsumi K, Sekizawa Y, Inoue M. In vitro antibacterial activity of a 9,3′-di-O-acetyl-midecamycin (MOM), a new macrolide antibiotic. Journal of Antibiotics 34: 436–442, 1981

    Article  Google Scholar 

  • Kees F, Grobecker H, Fourtillan JB, Tremblay D, Saint-Salvi B. Comparative pharmacokinetics of single dose roxithromycin (150mg) versus erythromycin stearate (500mg) in healthy volunteers. British Journal of Clinical Practice 42 (Suppl. 55): 51, 1988

    Google Scholar 

  • Kernbaum S. La spiramycine. Utilisation en thérapeutique humaine. Seminares Hopitalières Paris 58: 289–297, 1982

    CAS  Google Scholar 

  • Kessler M, Louis J, Renoult E, Vigneron B, Netter P. Interaction between cyclosporin and erythromycin in a kidney transplant patient. European Journal of Clinical Pharmacology 30: 633–634, 1986

    Article  PubMed  CAS  Google Scholar 

  • Kimelblatt BJ, Slaughter RL. Lack of effect of intravenous erythromycin lactobionate on theophylline clearance. Journal of Allergy and Clinical Immunology 65: 314–315, 1980

    Article  Google Scholar 

  • Kosmidis J, Marosis K. Concentration of erythromycin in sputum of patients with chronic bronchitis. Chemioterapia 4 (Suppl. 2): 346, 1985

    Google Scholar 

  • Kreft-Jais C, Billaud EM, Gaudry C, Bedrossian J. Effect of josamycin on plasma cyclosporine levels. European Journal of Clinical Pharmacology 32: 327–328, 1987

    Article  PubMed  CAS  Google Scholar 

  • Kroboth PD, Brown A, Lyon JA, Kroboth FJ, Juhl RP. Pharmacokinetics of single-dose erythromycin in normal and alcoholic liver disease subjects. Antimicrobial Agents and Chemotherapy 21: 135–140, 1982

    Article  PubMed  CAS  Google Scholar 

  • Kucers A, Bennet NMcK. Erythromycin. In The use of antibiotics. A comprehensive review with clinical emphasis, 4th ed., pp. 851–882, William Heinemann Medical Books, London, 1987

    Google Scholar 

  • Kunin CM. A guide to use of antibiotics in patients with renal disease. Annals of Internal Medicine 67: 151–158, 1967

    PubMed  CAS  Google Scholar 

  • Laforce CF, Szeffler SJ, Miller MF, Elbing W, Brenner M. Inhibition of methylprednisolone elimination in the presence of erythromycin therapy. Journal of Allergy and Clinical Immunology 72: 34–39, 1983

    Article  PubMed  CAS  Google Scholar 

  • Lagier G, Castot A, Riboulet G, Boesch C. Un cas d’ergotisme mineur semblant en rapport avec une potentialisation de l’ergotamine par l’ethylsuccinate d’érythromycine. Thérapie 34: 515–521, 1979

    PubMed  CAS  Google Scholar 

  • Lamy P, Anthoine D, Zuck P, Weber M, Baudesson D. Etude pharmacocinétique de la spiramycine en pathologie infectieuse respiratoire. Annales Médicale de Nancy 16: 109–112, 1977

    Google Scholar 

  • Larcan A. L’ergotisme thérapeutique. Journal of Pharmacology 10: 413–430, 1979

    Google Scholar 

  • Larrey D, Funck-Brentano C, Breil P, Vitaux J, Théodore C, et al. Effects of erythromycin on hepatic drug-metabolizing enzymes in humans. Biochemical Pharmacology 32: 1063–1068, 1983a

    Article  PubMed  CAS  Google Scholar 

  • Larrey D, Tinel M, Pessayre D. Formation of inactive cytochrome P-450 Fe(II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats. Biochemical Pharmacology 32: 1487–1493, 1983b

    Article  PubMed  CAS  Google Scholar 

  • Lassman HB, Puri SK, Ho I, Sabo R, Barry A. Influence of food on the absorption of RU 28965 (a new macrolide antibiotic) from film-coated tablets in healthy men. In Butzler & Kobayashi (Eds) Macrolides: a review with an outlook on future developments, pp. 138–142, Excerpta Medica, Amsterdam, 1986

    Google Scholar 

  • Lavarenne J, Paire M, Talon O. Influence d’un nouveau macrolide, la midécamycine, sur les taux sanguins de théophylline. Thérapie 36: 451–456, 1981

    PubMed  CAS  Google Scholar 

  • Lebrec D, Benhamou JP, Fourtillan JB, Tremblay D, Saint-Salvi B, et al. Roxithromycin: pharmacokinetics in patients suffering from alcoholic cirrhosis. British Journal of Clinical Practice 42 (Suppl. 55): 63, 1988

    Google Scholar 

  • Lee CC, Anderson RC, Chen KK. The excretory products of N-methyl-14C-erythromycin in rats. Journal of Pharmacology and Experimental Therapeutics 117: 274–280, 1956

    PubMed  CAS  Google Scholar 

  • Le Roux Y, Desnottes JF, Frydman AM, Kaplan PH, Gaillot J, et al. Pharmacokinetics of spiramycin after single and multiple administration of a one-hour 500mg i.v. infusion in healthy volunteers. In Ishigami (Ed.) Recent advances in chemotherapy. Proceedings of the 14th International Congress of Chemotherapy, Kyoto, 23–28 June 1985. Antimicrobial Section 1, pp. 734–735, University of Tokyo Press, Tokyo, 1985

    Google Scholar 

  • Lin C, Chung M, Gural R, Schuessler D, Kim M, et al. Pharmacokinetics and metabolism of rosaramicin in humans. Antimicrobial Agents and Chemotherapy 26: 522–526, 1984a

    Article  PubMed  CAS  Google Scholar 

  • Lin C, Kim H, Marco A, Radwanski E, Symchowicz S. Pharmacokinetics and metabolism of 14C rosaramicin in dogs. Antimicrobial Agents and Chemotherapy 29: 753–756, 1986

    Article  PubMed  CAS  Google Scholar 

  • Lin C, Kim H, Schuessler D, Oden E, Symchowicz S. High-pressure liquid chromatographic method for determination of rosaramicin in humans. Antimicrobial Agents and Chemotherapy 18: 780–783, 1980

    Article  PubMed  CAS  Google Scholar 

  • Lin C, Puar S, Schuessler D, Prananik BN, Symchowicz S. Isolation and identification of a metabolite of rosaramicin in human urine. Drug Metabolism and Disposition 12: 51–56, 1984b

    PubMed  CAS  Google Scholar 

  • Macfarlane JA, Mitchell AAB, Walsh JM, Roverbson JJ. Spiramycin in the prevention of postoperative staphylococcal infections. Lancet 1: 1–4, 1968

    Article  PubMed  CAS  Google Scholar 

  • Maddux MS, Leeds NH, Organek HW, Hasegawa GR, Bauman JL. The effect of erythromycin on theophylline pharmacokinetics at steady state. Chest 81: 563–565, 1982

    Article  PubMed  CAS  Google Scholar 

  • Magliulo E, Bonizzoni D, Concia E. La diffusibilità degli antibiotici nel fluido interstiziale umano. Influenza del legame proteico nella metodica della ‘skin-window’. Chemioterapia Antimicrobica 2: 368–377, 1979

    Google Scholar 

  • Magliulo E, Gandini T, Fumarola D, Maggiolo F, Maggiolo M, et al. Studio sul potere di diffusione di due antibiotici macrolidi in fluidi extravascolari umani. Giornale Italiano di Chemioterapia 29 (Suppl. 1): 89–101, 1982

    PubMed  Google Scholar 

  • Malmborg AS. Effect of food on absorption of erythromycin. A study of two derivatives, the stearate and the base. Journal of Antimicrobial Chemotherapy 5: 591–599, 1979

    Article  PubMed  CAS  Google Scholar 

  • Manzo L, Gregotti C, Richelmi P, Di Nucci A, Bertè F. Effects of phenobarbitone on the distribution, metabolism and biliary excretion of erythromycin in rats. Chemotherapy 26: 164–170, 1980

    Article  PubMed  CAS  Google Scholar 

  • Martin JR, Johnson P, Miller MF. Uptake, accumulation, and egress of erythromycin by tissue culture cells of human origin. Antimicrobial Agents and Chemotherapy 27: 314–319, 1985

    Article  PubMed  CAS  Google Scholar 

  • May DC, Jarboe CH, Ellenburg DT, Roe EJ, Karibo J. The effects of erythromycin on theophylline elimination in normal males. Journal of Clinical Pharmacology 22: 125–130, 1982

    PubMed  CAS  Google Scholar 

  • McDonald PJ. Macrolide antibiotics — pharmacology and the importance of formulation. In Butzler & Kobayashi (Eds) Macrolides: a review with an outlook on future developments, pp. 22–29, Excerpta Medica, Amsterdam, 1986

    Google Scholar 

  • McDonald PJ, Mather LE, Story MJ. Studies on absorption of a newly developed enteric-coated erythromycin base. Journal of Clinical Pharmacology 17: 601–606, 1977

    Article  PubMed  CAS  Google Scholar 

  • McLean A, Sutton JA, Salmo J, Chatelet D. Roxithromycin — pharmacokinetic and metabolism study in humans. British Journal of Clinical Practice 42 (Suppl. 55): 52–53, 1988

    Google Scholar 

  • Meirovich CI, Montrull H, Strusberg AM, Brizuela N, Forti IN. Roxithromycin levels in synovial fluid. British Journal of Clinical Practice 42 (Suppl. 55): 88, 1988

    Google Scholar 

  • Mesdjian E, Dravet C, Cenraud B, Roger J. Carbamazepine intoxication due to triacetyloleandomycin administration in epileptic patients. Epilepsia 21: 489–490, 1980

    Article  PubMed  CAS  Google Scholar 

  • Miguet JP, Vuitton D, Pessayre D, Allemand H, Metreau JM, et al. Jaundice from troleandomycin and oral contraceptives. Archives of Internal Medicine 92: 434, 1980

    CAS  Google Scholar 

  • Miller MF, Martin JR, Johnson P, Ulrich JT, Rdzok EJ, et al. Erythromycin uptake and accumulation by human polymorphonuclear leukocytes and efficacy of erythromycin in killing ingested Legionella pneumophila. Journal of Infectious Diseases 149: 714–718, 1984

    Article  PubMed  CAS  Google Scholar 

  • Mini E, Mazzei T, Reali EF, Periti P. Penetration of the new macrolide roxithromycin (RU 28965) into lung tissue and suction blister fluid. In Berkarda & Kuemmerle (Eds) Progress in chemotherapy. Proceedings of the 15th International Congress of Chemotherapy, Istanbul, 19–24 July, 1987. Antimicrobial Section Vol. 1, pp. 1350–1352, Ecomed, Landsberg, 1987

    Google Scholar 

  • Mitsuhashi S (Ed.). Drug action and drug resistance in bacteria, University Park Press, Tokyo, 1971

    Google Scholar 

  • Nicholas P. Erythromycin: clinical review. I. Clinical pharmacology. New York State Journal of Medicine 77: 2088–2096, 1977

    PubMed  CAS  Google Scholar 

  • Nicoletti P, Novelli A, Mazzei T, Lamanna S, Periti P. Clinical, pharmacokinetic and antimicrobial evaluation of josamycin in comparison with other macrolide antibiotics. In Spitzy & Karrer (Eds) Proceedings of the 13th International Congress of Chemotherapy, Vienna, 28 August–2 September, 1983. Vol. 5, pp. SS 4.4/1–6, 36/29-32, Egermann Druckereigesellschaft, 1983a

  • Nicoletti P, Rizzo M, Mazzei T, Novelli A, Ciuffi M, et al. Aspetti farmacocinetici della miocamicina. Chemioterapia 2 (Suppl. 3): 140–141, 1983b

    Google Scholar 

  • Nilsen OG. Comparative pharmacokinetics of macrolides. Journal of Antimicrobial Chemotherapy 20 (Suppl. B): 81–88, 1987

    PubMed  CAS  Google Scholar 

  • Nilsen O, Saint-Salvi B, Lenfant B, Tremblay D, Manuel C. Pharmacokinetics of roxithromycin in the elderly — linearity and repeat dose studies. British Journal of Clinical Practice 42 (Suppl. 55): 59–60, 1988

    Google Scholar 

  • Nishimura T. Clinical studies of miocamycin (9,3′-diacetylmidecamycin) in children and adults. Chemioterapia 2 (Suppl. 5): 289–290, 1983

    Google Scholar 

  • Okolicsanyi L, Venuti M, Strazzabosco M, Biral A, Orlando R, et al. Pharmacokinetics of josamycin in patients with liver cirrhosis and Gilbert’s syndrome after repeated doses. International Journal of Clinical Pharmacology, Therapy and Toxicology 23: 434–438, 1985

    CAS  Google Scholar 

  • Osono T, Umezawa H. Pharmacokinetics of macrolides, lincosamides and streptogramins. Journal of Antimicrobial Chemotherapy 16 (Suppl. A): 151–166, 1985

    PubMed  CAS  Google Scholar 

  • Paavolainen M, Kohonen A, Palva T, Renkonen OV. Penetration of erythromycin stearate into maxillary sinus mucosa and secretion in chronic maxillary sinusitis. Acta Oto-Laryngologica 84: 292–295, 1977

    Article  PubMed  CAS  Google Scholar 

  • Paire M, Lavarenne J. Interactions médicamenteuses avec les macrolides: action comparée de deux macrolides sur l’activité des macrosomes hépatiques. Pathologie Biologie 30: 535–538, 1982

    PubMed  CAS  Google Scholar 

  • Patamasucon P, Kaojarern S, Kusmiesz H, Nelson JD. Pharmacokinetics of erythromycin ethylsuccinate and estolate in infants under 4 months of age. Antimicrobial Agents and Chemotherapy 19: 736–739, 1981

    Article  PubMed  CAS  Google Scholar 

  • Paulsen O, Hoglund P, Nilsson L-G, Bengtsson H-I. The interaction of erythromycin with theophylline. European Journal of Clinical Pharmacology 32: 493–498, 1987

    Article  PubMed  CAS  Google Scholar 

  • Periti P, Fini-Storchi O, Novelli A, Ninu MD, Bordonaro P, et al. Penetrazione nella mucosa nasale délia eritromicina somministrata per via orale sotto forma del sale mercaptosuccinato del propilestere (RV11 Pierrel). Farmaci e Terapia 3: 194–197, 1986a

    Google Scholar 

  • Periti P, Marino C, Novelli A, Bordonaro P, Reali EF, et al. Valutazione farmacocinetica clinica della eritromicina propionato d,l-mercaptosuccinato(RV11 Pierrel). Farmaci e Terapia 3: 189–193, 1986b

    Google Scholar 

  • Periti P, Mazzei T. Pharmacokinetics of roxithromycin in renal and hepatic failure and drug interactions. Journal of Antimicrobial Chemotherapy 20 (Suppl. B): 107–112, 1987

    PubMed  Google Scholar 

  • Pessayre D, Descatoire V, Konstantinova-Mitcheva M, Wandsheer JC, Cobert B, et al. Self induction by triacetyloleandomycin of its own transformation into a metabolite forming a stable 456nm-absorbing complex with cytochrome P-450. Biochemical Pharmacology 30: 553–558, 1981

    Article  PubMed  CAS  Google Scholar 

  • Pessayre D, Larrey D, Funck-Brentano C, Benhamou JP. Drug interactions and hepatitis produced by some macrolide antibiotics. Journal of Antimicrobial Chemotherapy 16 (Suppl. H): 181–194, 1985

    PubMed  CAS  Google Scholar 

  • Pfeifer HJ, Greenblatt DJ, Friedman P. Effects of three antibiotics on theophylline kinetics. Clinical Pharmacology and Therapy 26: 36–40, 1979

    CAS  Google Scholar 

  • Philipson A, Sabath LD, Charles D. Transplacental passage of erythromycin and clindamycin. New England Journal of Medicine 288: 1219–1221, 1973

    Article  PubMed  CAS  Google Scholar 

  • Pignanelli M, Calderari G, Fraschini F, Moro GF, Tassarotti B. Concentrazioni di antibiotici macrolidici in alcuni tessuti ascellari. Dental Cadmos 3: 91–94, 1984

    Google Scholar 

  • Pocidalo JJ, Albert F, Desnottes JF, Kernbaum S. Intraphagocytic penetration of macrolides: in-vivo comparison of erythromycin and spiramycin. Journal of Antimicrobial Chemotherapy 16 (Suppl. A): 167–173, 1985

    PubMed  CAS  Google Scholar 

  • Posti J, Salonen M. Effect of formulation factors and food intake on the bioavailability of erythromycin stearate. International Journal of Pharmacy 17: 225–253, 1983

    Article  CAS  Google Scholar 

  • Pozzi E, Ferrara A, Sardi A, Berti MA, Coppi G. Bioavailability studies on erythromycin administered by rectal and oral routes. Current Therapeutic Research 31: 530–535, 1982

    CAS  Google Scholar 

  • Prince RA, Wing DS, Weinberger MM, Hendeles LS, Riegelman S. Effect of erythromycin on theophylline kinetics. Journal of Allergy and Clinical Immunology 68: 427–431, 1981

    Article  PubMed  CAS  Google Scholar 

  • Prokesch RC, Hand LW. Antibiotic entry into human polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy 21: 373–380, 1982

    Article  PubMed  CAS  Google Scholar 

  • Puri SK, Lassman HB. Roxithromycin: a pharmacokinetic review of a macrolide. Journal of Antimicrobial Chemotherapy 20 (Suppl. B): 89–100, 1987

    PubMed  CAS  Google Scholar 

  • Puri SK, Lassman HB, Ho I, Sabo R, Barry A. Safety, tolerance, and pharmacokinetics of single and multiple oral doses of RU28695 (a new macrolide antibiotic) in healthy men. In Butzler & Kobayashi (Eds) Macrolides: a review with an outlook on future developments, pp. 128–137, Excerpta Medica, Amsterdam, 1986

    Google Scholar 

  • Raeder K, Wildfeuer A, Schwedass A, Laufen H. Determination of josamycin in plasma, erythrocytes and leukocytes via high-performance liquid chromatography by direct injection of plasma or homogenized blood cells, using alternating sample clean-up columns. Journal of Chromatography 344: 416–421, 1985

    Article  CAS  Google Scholar 

  • Retsema J, Girard A, Schelkly W, Manousos M, Anderson M, et al. Spectrum and mode of action of azithromycin (CP-62, 993), a new 15-membered-ring macrolide with improved potency against Gram-negative organisms. Antimicrobial Agents and Chemotherapy 31: 1939–1947, 1987

    Article  PubMed  CAS  Google Scholar 

  • Ridgway GL. Antimicrobial chemotherapy of chlamydial infection: where next? European Journal of Clinical Microbiology 5: 550–553, 1986

    Article  PubMed  CAS  Google Scholar 

  • Rimoldi R, Mangiarotti P, De Rose V, Nonis A, Bertoletti R, et al. Penetration of roxithromycin into bronchial secretions. British Journal of Clinical Practice 41 (Suppl. 55): 74–77, 1988

    Google Scholar 

  • Rolston KVI, LeBlanc B, Ho DH. In vitro activity of RU 28965, a new macrolide, compared to that of erythromycin. Journal of Antimicrobial Chemotherapy 17: 161–163, 1986

    Article  PubMed  CAS  Google Scholar 

  • Ruff F, Prosper M, Pujet JC. Théophylline et antibiotiques. Absence d’interaction avec la josamycine. Thérapie 39: 1–6, 1984

    PubMed  CAS  Google Scholar 

  • Rutland J, Berend N, Marlin GE. The influence of food on the bioavailability of new formulations of erythromycin stearate and base. British Journal of Clinical Pharmacology 8: 343–347, 1979

    Article  PubMed  CAS  Google Scholar 

  • Sabath LD, Anhalt JP. Assay of antimicrobics. In Lenette et al. (Eds) Manual of clinical microbiology, pp. 485–490, American Society for Microbiology, Washington D.C., 1980

    Google Scholar 

  • Sabath LD, Gerstain DA, Bronwen Loder P, Finland M. Excretion of erythromycin and its enhanced activity in urine against Gram-negative bacilli with alkalinization. Journal of Laboratory and Clinical Medicine 72: 916–923, 1968

    PubMed  CAS  Google Scholar 

  • Saint-Salvi B, Tremblay D, Surjus A, Lefebvre MA. A study of interaction of roxithromycin with theophylline and carbamazepine. Journal of Antimicrobial Chemotherapy 20 (Suppl. B): 121–129, 1987

    PubMed  CAS  Google Scholar 

  • Saito A, Nasu M, Hara K, Sawatari K, Hayashi A, et al. Fundamental studies on mydecamycin (SF-837), a new macrolide antibiotic, and its application in respiratory tract infections. Chemotherapy 21(4): 762–771, 1973

    CAS  Google Scholar 

  • Sanders SW, Jaeger H, Cunci R, Fujita M, Maurette JM. Single and multiple dose pharmacokinetics and tolerance of miocamycin in healthy European volunteers. In Ishigami (Ed.) Recent advances in chemotherapy. Proceedings of the 14th International Congress of Chemotherapy, Kyoto, 23–28 June 1985. Antimicrobial Section 2, pp. 1452–1453, University of Tokyo Press, Tokyo, 1985

    Google Scholar 

  • Sawae Y, Kumagai Y, Ishimaru T. Antimicrobial activity and pharmacokinetics of miocamycin, and its clinical usefulness. In Berkarda (Ed.) Progress in chemotherapy. Proceedings of the 15th International Congress of Chemotherapy, Istanbul, 19–24 July, 1987. Antimicrobial Section Vol. 1, pp. 165–167, Ecomed, Landsberg, 1987

    Google Scholar 

  • Selles JPh, Panis G, Jaber H, Bres J, Armando P. Influence of josamycine on theophylline kinetics. In Spitzy & Karrer (Eds) Proceedings of the 13th International Congress of Chemotherapy, Vienna, 28 August–2 September 1983, SS 4.4/1–3, pp. 36/15–20, Egermann Druckereigesellschaft, 1983

  • Segre G, Bianchi E, Zanolo G, Bartucci F, Sassella D. Influence of food on the bioavailability of roxithromycin versus erythromycin stearate. British Journal of Clinical Practice 42 (Suppl. 55): 55–57, 1988

    Google Scholar 

  • Segui A, Milon D, Cormier M, Lepesant G. Erythromycin lactobionate: pharmacokinetics and uterine tissue levels. European Journal of Drug Metabolism and Pharmacokinetics 12: 153–160, 1987

    Article  PubMed  CAS  Google Scholar 

  • Shadomy S, Tipple M, Paxton T. Josamycin and rosaramycin: in vitro comparisons with erythromycin and clindamycin. Antimicrobial Agents and Chemotherapy 10: 773–775, 1976

    Article  PubMed  CAS  Google Scholar 

  • Shanson DC, McNabb WR, Ruby K. High dose erythromycin for preventing endocarditis. Lancet 1: 299–300, 1983

    Article  PubMed  CAS  Google Scholar 

  • Shanson DC, Tidbury P, McNabb WR, Tadayon M. The pharmacokinetics and tolerance of oral erythromycin stearate compared with erythromycin ethylsuccinate: implications for preventing endocarditis. Journal of Antimicrobial Chemotherapy 14: 157–163, 1984

    Article  PubMed  CAS  Google Scholar 

  • Shepard RM. High pressure liquid chromatographic (HPCL) assay for azithromycin (CP-62993/XZ-450) in serum and tissues. Interscience Conference on Antimicrobial Agents and Chemotherapy, New York, 4–7 October, 1987. Abstract 238, p. 138, 1987

  • Shepard RM, Weidler DJ, Garg DC, Madsen PO, Cox CE, et al. Human pharmacokinetics of azithromycin (CP-62, 993/XZ-450), a new macrolide with an extended half-life and high tissue penetration. Interscience Conference on Antimicrobial Agents and Chemotherapy, New York, 4–7 October, 1987. Abstract 239, p. 138, 1987

  • Shiiki K, Sakamoto H. Penetration of antimicrobial agents into saliva (clinical application as a therapeutic drug monitoring method). Progress in Chemotherapy. 15th International Congress of Chemotherapy, Istanbul, 19–24 July, 1987. Antimicrobial Section Vol. 1, pp. 211–213, Ecomed, Landsberg, 1987

    Google Scholar 

  • Shomura T, Umemura K. Studies on absorption, distribution, metabolism and excretion of a new macrolide antibiotic SF-837. I. Absorption, metabolism and excretion of SF-837. Chemical and Pharmaceutical Bulletin 21: 1824–1831, 1973

    Article  CAS  Google Scholar 

  • Spitzy KH, Hitzenberger G. The distribution volume of some antibiotics. Antibiotics Annual 1957, 996–1003, 1958

    Google Scholar 

  • Steigbigel NH. Erythromycin, lincomycin and clindamycin. In Mandel et al. (Eds) Anti-infective therapy, pp. 197–218, John Wiley and Sons, New York, 1985

    Google Scholar 

  • Stoehr GP, Juhl RP, Veals J, Symchowicz S, Gural R, et al. The excretion of rosaramicin in breast milk. Journal of Clinical Pharmacology 25: 89–94, 1985

    PubMed  CAS  Google Scholar 

  • Strausbaugh LJ, Bolton WK, Dilworth JA, Guerrant RL, Sande MA. Comparative pharmacology of josamycin and erythromycin stearate. Antimicrobial Agents and Chemotherapy 10: 450–456, 1976

    Article  PubMed  CAS  Google Scholar 

  • Stubbs C, Haigh JM, Kanfer I. Determination of erythromycin in serum and urine by high-performance liquid chromatography with ultraviolet detection. Journal of Pharmaceutical Sciences 74: 1126–1128, 1985

    Article  PubMed  CAS  Google Scholar 

  • Sundberg L, Edén T, Ernston S. Penetration of erythromycin in Waldeyer’s ring-adenoid tissue. Acta Oto-Laryngologica (Suppl. 384): 3–9, 1981

    Google Scholar 

  • Sundberg L, Eden T, Ernstson S, Pahlitzsch R. Penetration of erythromycin through respiratory mucosa. A study using secretary otitis media as a mode. Acta Oto-Laryngologica 365 (Suppl.): 1–17, 1979

    Article  CAS  Google Scholar 

  • Szefler SJ, Rose JQ, Ellis EF, Spector SL, Green AW, et al. The effect of troleandomycin on methylprednisolone elimination. Journal of Allergy and Clinical Immunology 66: 447–451, 1980

    Article  PubMed  CAS  Google Scholar 

  • Thompson PJ, Burgess KR, Marlin GE. Influence of food on absorption of erythromycin ethyl succinate. Antimicrobial Agents and Chemotherapy 18: 829–831, 1980

    Article  PubMed  CAS  Google Scholar 

  • Taranger C, Pons M, Tamalet J, Videau D. Action de la spiramycine sur le pouvoir pathogène et la croissance de bactéries Gram-positif. Pathologie & Biologie 20: 961–964, 1972

    CAS  Google Scholar 

  • Tremblay D, Bryskier A, Vuckovic M, Stockis A, Manuel C. RU 28965, nouveau macrolide semi-synthétique: biodisponibilité et profil pharmacocinétique après administration par voie orale. Pathologie Biologie 33: 502–506, 1985

    PubMed  CAS  Google Scholar 

  • Tremblay D, Jaeger H, Fourtillan JB, Manuel C. Pharmacokinetics of three single doses (150, 300, 450mg) of roxithromycin in young volunteers. British Journal of Clinical Practice 42 (Suppl. 55): 49–50, 1988a

    Google Scholar 

  • Tremblay D, Meyer B, Saint-Salvi B, Robinet D. Influence of food on bioavailability of roxithromycin (RU 28965). 3rd World Conference of Clinical Pharmacology and Therapeutics, Stockholm. Abstract No. 1206, 1986

  • Tremblay D, Mignot A, Couraud L, Saux MC, Manuel C. Concentrations of roxithromycin in lung tissue after repeat dosing. British Journal of Clinical Practice 42 (Suppl. 55): 73, 1988b

    Google Scholar 

  • Tremblay D, Verger C, Saint-Salvi B, Robinet D, Manuel C. Pharmacokinetics of roxithromycin in chronic renal insufficiency. British Journal of Clinical Practice 42 (Suppl. 55): 61–62, 1988c

    Google Scholar 

  • Tserng KY, Wagner JG. Fluorometric determination of erythromycin and erythromycin propionate in whole blood or plasma and correlation of results with microbiological assay. Analytical Chemistry 48: 348–353, 1976

    Article  PubMed  CAS  Google Scholar 

  • Tsuji K. Fluorimetric determination of erythromycin ethylsuccinate in serum by high performance liquid chromatographic post-column, on-stream derivatization and extraction method. Journal of Chromatography 158: 337–348, 1978

    Article  PubMed  CAS  Google Scholar 

  • Twiss RJ, Berger WV, Gillette L, Arnonson AR, Siegel L. The biliary excretion of erythromycin (ilotycin). Surgery, Gynecology and Obstetrics 102: 355–357, 1956

    PubMed  CAS  Google Scholar 

  • Vaillant L, Lorette G, Loulergue J, Audurier A. Erythromycin ethylsuccinate: diffusion through interstitial dermal fluid. European Journal of Clinical Pharmacology 33: 529–530, 1987

    Article  PubMed  CAS  Google Scholar 

  • Venho VMK, Palva ES, Konno K, Stenfors E. The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate. Methods and Findings in Experimental and Clinical Pharmacology 9: 445–447, 1987

    PubMed  CAS  Google Scholar 

  • Videau D. La spiramycine: bactériologie, pharmacologie, pharmacocinétique et distribution tissulaire. Cahiers de Médicine Vétérinaire 47: 155–164, 1978

    Google Scholar 

  • Villa P, Sassella D, Corada M, Bartosek I. Toxicity, uptake and subcellular distribution of roxithromycin and erythromycin base in rat hepatocytes. British Journal of Clinical Practice 42 (Suppl. 55): 64–66, 1988

    Google Scholar 

  • Vincon G, Albin H, Demotes-Mainard F, Guyot M, Bistue C, et al. Effects of josamycin on carbamazepine kinetics. European Journal of Clinical Pharmacology 32: 321–323, 1987

    Article  PubMed  CAS  Google Scholar 

  • Vosbeck K, James PR, Zimmermann W. Antibiotic action of phagocytosed bacteria measured by a new method for determining viable bacteria. Antimicrobial Agents and Chemotherapy 25: 735–742, 1984

    Article  PubMed  CAS  Google Scholar 

  • Walsh M, Kappus EW, Quinn TC. In vitro evaluation of CP-62,993, erythromycin, clindamycin, and tetracycline against Chlamydia trachomatis. Antimicrobial Agents and Chemotherapy 31: 811–812, 1987

    Article  PubMed  CAS  Google Scholar 

  • Walstad RA, Hellum KB. Penetration of erythromycin in respiratory tract infections. Acta Oto-Laryngologica (Suppl. 407): 50–54, 1984

    Google Scholar 

  • Washington JA II, Wilson WR. Erythromycin: a microbial and clinical perspective after 30 years of clinical use (second of two parts). Mayo Clinic Proceedings 60: 271, 1985

    PubMed  Google Scholar 

  • Weinberger M, Hudgel D, Spector S, Chidseu C. Inhibition of theophylline clearance by troleandomycin. Journal of Allergy and Clinical Immunology 59: 228–231, 1977

    Article  PubMed  CAS  Google Scholar 

  • Welling PG. Effect of food on bioavailability of drugs. Pharmacy International 1: 14–18, 1980

    CAS  Google Scholar 

  • Welling PG, Tse FLS. The influence of food on the absorption of antimicrocial agents. Journal of Antimicrobial Chemotherapy 9: 7–27, 1982

    Article  PubMed  CAS  Google Scholar 

  • Wiggins J, Arbab O, Ayres JG, Skinner C. Elevated serum theophylline concentration following cessation of erythromycin treatment. European Journal of Respiratory Diseases 68: 298–300, 1986

    PubMed  CAS  Google Scholar 

  • Wildfeuer A, Laufen H, Rader K. Activity of josamycin in human tissue and neutrophils. In Ishigami (Ed.) Recent advances in chemotherapy. Proceedings of the 14th International Congress of Chemotherapy, Kyoto, 23–28 June, 1985. Antimicrobial Section 2, pp. 1478–1480, University of Tokyo Press, Tokyo, 1985

    Google Scholar 

  • Wiley PE. Macrolide antibiotics. In Kuemmerle et al. (Eds) Clinical chemotherapy, Vol. II, pp. 163–176, Thierne-Stratton Inc., New York, 1983

    Google Scholar 

  • Wilson JT, Van Boxtel CJ. Pharmacokinetics of erythromycin in man. In Schonfeld (Ed.) Antibiotics and chemotherapy 25: 181–203, 1978

    Google Scholar 

  • Wise R, Kirkpatrick B, Asby J, Andrews JM. Pharmacokinetics and tissue penetration of roxithromycin after multiple dosing. Antimicrobial Agents and Chemotherapy 31: 1051–1053, 1987

    Article  PubMed  CAS  Google Scholar 

  • Wollmer P, Rhodes CG, Pike VW, Silvester DJ, Pride NB, et al. Measurement of pulmonary erythromycin concentration in patients with lobar pneumonia by means of positron tomography. Lancet 2: 1361–1364, 1982

    Article  PubMed  CAS  Google Scholar 

  • Wong YY, Ludden TM, Bell RD. Effect of erythromycin on carbamazepine kinetics. Clinical Pharmacology and Therapeutics 33: 460–464, 1983

    Article  PubMed  CAS  Google Scholar 

  • Yakatan GJ, Poynor WJ, Harris RG, Martin A, Leonard RG, et al. Single-dose fasting bioequivalence assessment of erythromycin stearate tablets in man. Journal of Pharmacokinetics and Biopharmaceutics 7: 355–368, 1979

    PubMed  CAS  Google Scholar 

  • Yakatan GJ, Poynor WJ, Breeding SA, Lankford CE, Dighe SV, et al. Single- and multiple-dose bioequivalence of erythromycin pharmaceutical alternatives. Journal of Clinical Pharmacology 20: 625–638, 1980

    PubMed  CAS  Google Scholar 

  • Yakatan GJ, Rasmussen CE, Feis PJ, Wallen S. Bioinequivalence of erythromycin ethylsuccinate and enteric-coated erythromycin pellets following multiple oral doses. Journal of Clinical Pharmacology 25: 36–42, 1985

    PubMed  CAS  Google Scholar 

  • Young RA, Gonzalez JP, Sorkin EM. Roxithromycin: a review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs 37: 8–41, 1989

    Article  PubMed  CAS  Google Scholar 

  • Zini R, Fournet MP, Barre J, Tremblay D, Tillement JP. In vitro study of roxithromycin binding to serum proteins and erythrocytes in humans. British Journal of Clinical Practice 42 (Suppl. 55): 54, 1988

    Google Scholar 

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  1. Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Morgagni, 65, 50134, Florence, Italy

    Piero Periti, Teresita Mazzei, Enrico Mini & Andrea Novelli

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Periti, P., Mazzei, T., Mini, E. et al. Clinical Pharmacokinetic Properties of the Macrolide Antibiotics. Clin-Pharmacokinet 16, 261–282 (1989). https://doi.org/10.2165/00003088-198916050-00001

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