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Is Skeletal Muscle Oxidative Capacity Decreased in Old Age?

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Abstract

In humans, decreases in cardiac output play an important role in the age-related decrease in whole-body oxidative capacity. What remains less clear is whether a decline in skeletal muscle oxidative capacity is also an inevitable consequence of aging, as a number of other factors that could affect oxidative capacity also change with age, including: physical activity, health status, fibre-type composition, rates of protein synthesis and muscle blood supply. Both in vitro studies using muscle biopsy tissue and in vivo studies using 31P-magnetic resonance spectroscopy are used to study muscular oxidative capacity. Using these methodologies, researchers have found age-associated reductions in the oxidative capacities of specific muscles. In most cases, however, the influence of physical activity has not been adequately controlled, making it difficult to evaluate the effects of age itself from those of lifestyle changes associated with aging.

Upon critical evaluation of the existing literature, the following picture regarding the effect of age on muscle oxidative capacity appears: although the maximum level of muscular oxidative capacity attainable through training may decline with age, much of the age-associated decline in oxidative function is related to the reductions in fitness and/or habitual physical activity that typically occur in this population. Future studies in this area must account for the health and activity status of their study participants.

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Acknowledgements

This work was supported by NIH R01 AG21094. The authors have no conflicts of interest that are directly relevant to the content of this review.

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  1. University of Massachusetts, Amherst, Massachusetts, USA

    David W. Russ & Jane A. Kent-Braun

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  1. David W. Russ
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Russ, D.W., Kent-Braun, J.A. Is Skeletal Muscle Oxidative Capacity Decreased in Old Age?. Sports Med 34, 221–229 (2004). https://doi.org/10.2165/00007256-200434040-00002

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