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‘Hedged’ Prescribing for Partially Compliant Patients

How Accurate Are Available Scaling Methods?

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Table I

Notes

  1. The use of trade names is for product identification purposes only and does not imply endorsement.

References

  1. Merriam-Webster’s Collegiate Dictionary, 10th ed. Springfield (MA): Merriam-Webster, Inc., 2001

  2. Blesius A, Chabaud S, Cucherat M, et al. Compliance-guided therapy: a new insight into the potential role of clinical pharmacologists. Clin Pharmacokinet 2005; 45(1): 95–104

    Article  Google Scholar 

  3. Urquhart J. Variable compliance and persistence with prescribed drug dosing regimens: implications for benefits, risks, and economics of pharmacotherapy. In: Strom B, editor. Pharmacoepidemiology. 4th ed. Chichester: John Wiley, 2005: 767–89

    Google Scholar 

  4. Potter LS. Oral contraceptive compliance and its role in the effectiveness of the method. In: Cramer JA, Spilker B, editors. Compliance in medical practice and clinical trials. New York: Raven Press, 1991: 195–207

    Google Scholar 

  5. Guillebaud J. Any questions. BMJ 1993; 307: 617

    Google Scholar 

  6. “What to do if you miss pills”? In: Physicians’ desk reference. 59th ed. Montvale (NJ): Medical Economics Co.: 2541

  7. Ten great public health achievements US, 1900–99: family planning. MMWR 1999; 48: 1073-80

    Google Scholar 

  8. Urquhart J. The odds of the three nons when an aptly prescribed medicine isn’t working: noncompliance, nonabsorption, non-response. Brit J Clin Pharmacol 2002; 54: 212–20

    Article  Google Scholar 

  9. Urquhart J. Controlled drug delivery: pharmacologic and therapeutic aspects. J Internal Med 2000; 248: 357–76

    Article  PubMed  CAS  Google Scholar 

  10. Vrijens B, Gross R, Urquhart J. The odds that clinically unrecognized poor or partial adherence confuses population pharmacokinetic/pharmacodynamic analyses. Basic Clin Pharmacol Toxicol 2005; 96: 225–7

    Article  PubMed  CAS  Google Scholar 

  11. Vrijens B, Comte L, Tousset E, et al. Once-daily versus twice-daily regimens: which is best for HIV-infected patients [abstract no. 3; poster no. 1.3]. 6th International Workshop on Clinical Pharmacology of HIV Therapy. 2005 Apr 28–30. Quebec City (QC)

  12. Levy G. A pharmacokinetic perspective on medicament non-compliance. Clin Pharmacol Ther 1993; 54: 242–4

    Article  PubMed  CAS  Google Scholar 

  13. Kruse W, Rampmaier J, Ullrich G, et al. Patterns of drug compliance with medication to be taken once and twice daily assessed by continuous electronic monitoring in primary care. Int J Clin Pharmacol Ther 1994; 32: 452–7

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. AARDEX Ltd, Zug, Switzerland

    John Urquhart & Bernard Vrijens

  2. Department of Biopharmaceutical Sciences, Center for Drug Development Science, University of California at San Francisco, San Francisco, California, USA

    John Urquhart

  3. Department of Biostatistics and Medical Informatics, University of Liège, Liège, Belgium

    Bernard Vrijens

Authors
  1. John Urquhart
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  2. Bernard Vrijens
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Urquhart, J., Vrijens, B. ‘Hedged’ Prescribing for Partially Compliant Patients. Clin Pharmacokinet 45, 105–108 (2006). https://doi.org/10.2165/00003088-200645010-00008

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