Suspected Aspergillus nodule histologically consistent with pulmonary nodular lymphoid hyperplasia:a case report

Shun Morizumi; Atsushi Morishita; Miho Nishiyama; Kiyohide Takahashi; Kenya Sumitomo; Hiroyuki Hino; Keishi Naruse; Eiji Takeuchi; Shoji Sakiyama; Tsutomu Shinohara

doi:10.2152/jmi.70.499

Shun Morizumi, Atsushi Morishita, Miho Nishiyama, Kiyohide Takahashi, Kenya Sumitomo, Hiroyuki Hino, Keishi Naruse, Eiji Takeuchi, Shoji Sakiyama, Tsutomu Shinohara

Author information

Shun Morizumi
Division of Internal Medicine, Japan Agricultural Cooperatives Kochi Hospital, Kochi, Japan
Department of Community Medicine for Respirology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan
Atsushi Morishita
Division of Thoracic Surgery, National Hospital Organization Kochi Hospital, Kochi, Japan
4Division of Surgery, National Hospital Organization Higashi Tokushima Medical Center, Tokushima, Japan
Miho Nishiyama
Division of Internal Medicine, Japan Agricultural Cooperatives Kochi Hospital, Kochi, Japan
Kiyohide Takahashi
Division of Internal Medicine, Japan Agricultural Cooperatives Kochi Hospital, Kochi, Japan
Kenya Sumitomo
Division of Internal Medicine, Japan Agricultural Cooperatives Kochi Hospital, Kochi, Japan
Hiroyuki Hino
Division of Thoracic Surgery, National Hospital Organization Kochi Hospital, Kochi, Japan
Keishi Naruse
Division of Clinical Laboratory, National Hospital Organization Kochi Hospital, Kochi, Japan
Eiji Takeuchi
Department of Clinical Investigation, National Hospital Organization Kochi Hospital, Kochi, Japan
Shoji Sakiyama
Division of Thoracic Surgery, National Hospital Organization Kochi Hospital, Kochi, Japan
Tsutomu Shinohara
Division of Internal Medicine, Japan Agricultural Cooperatives Kochi Hospital, Kochi, Japan
Department of Community Medicine for Respirology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan

Keywords: Aspergillus nodule, pulmonary nodular lymphoid hyperplasia, bronchus-associated lymphoid tissue

JOURNAL FREE ACCESS

2023 Volume 70 Issue 3.4 Pages 499-502

DOI https://doi.org/10.2152/jmi.70.499

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Abstract

Aspergillus nodules (AN) are an unusual form of chronic pulmonary aspergillosis. On the other hand, pulmonary nodular lymphoid hyperplasia (PNLH) is classified as a reactive pulmonary lymphoproliferative disorder. A 65-year-old male was referred to our hospital due to a nodule in the left upper lobe. Histologically, a mixture of prominent lymphoid follicular formation, and hyaline necrosis were observed. Grocott staining revealed morphological forms of Aspergillus spp. in the necrosis. The final clinical diagnosis was suspected AN histologically consistent with PNLH. This case suggests that there may be PNLH cases in which local infection with Aspergillus contributes to its pathophysiology. J. Med. Invest. 70 : 499-502, August, 2023

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