Translational and Randomized Study of 5-HT3 Receptor Antagonists for Evaluation of Chemotherapy-induced Nausea and Vomiting Related Biomarkers

Yukari Tsubata; Mika Nakao; Yoshihiro Amano; Takamasa Hotta; Megumi Hamaguchi; Tamio Okimoto; Kiyotaka Miura; Shunichi Hamaguchi; Takashige Kuraki; Masayuki Itakura; Takeshi Isobe

doi:10.2152/jmi.66.269

Yukari Tsubata, Mika Nakao, Yoshihiro Amano, Takamasa Hotta, Megumi Hamaguchi, Tamio Okimoto, Kiyotaka Miura, Shunichi Hamaguchi, Takashige Kuraki, Masayuki Itakura, Takeshi Isobe

Author information

Yukari Tsubata
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan
Mika Nakao
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan
Yoshihiro Amano
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan
Takamasa Hotta
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan
Megumi Hamaguchi
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan
Tamio Okimoto
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan
Kiyotaka Miura
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan
Shunichi Hamaguchi
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan
Takashige Kuraki
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan
Masayuki Itakura
Department of Surgery, Shimane University Faculty of Medicine, Shimane, Japan
Takeshi Isobe
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan

Keywords: Chemotherapy-induced nausea and vomiting (CINV), Self-assessment questionnaire, Quality of life (QOL), Emetic biomarkers, Ghrelin

JOURNAL FREE ACCESS

2019 Volume 66 Issue 3.4 Pages 269-274

DOI https://doi.org/10.2152/jmi.66.269

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Abstract

Purpose We assessed the efficacy of palonosetron (PAL) in comparison to granisetron (GRA) for the treatment of CINV using the self-assessment questionnaires. In addition, we analyzed the serum levels of emetic various biomarkers. Methods We conducted a randomized study of 70 patients naïve to chemotherapy. The primary endpoint was the late phase score on the MAT questionnaire. The plasma concentrations of the biomarkers were measured on days 1 and 3. Results There were no statistical differences in the scores on the questionnaires, but the mean values in response to PAL were higher than those in response to GRA. The value of ghrelin on day 1 was significantly higher for GRA than for PAL. Conclusions For the primary endpoint, the score of the late phase on the MAT questionnaire was not statistically different between the PAL and GRA treatment groups. Further studies are needed to clarify the role of ghrelin for the treatment of CINV. J. Med. Invest. 66 : 269-274, August, 2019

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