LACK OF INHIBITORY EFFECTS OF THE JU-MYO PROTEIN ON DEVELOPMENT OF GLUTATHIONE S-TRANSFERASE PLACENTAL FORM-POSITIVE FOCI IN THE MALE F344 RAT LIVER

Toshio ICHIHARA; Hideki WANIBUCHI; Chyi Chia R. LEE; Kazuhide NAKAJIMA; Yoshihisa YANO; Tetsuhide TANIYAMA; Shuzo OTANI; Yoshiharu SHIMIZU; Shoji FUKUSHIMA

doi:10.2131/jts.24.27

Toshio ICHIHARA, Hideki WANIBUCHI, Chyi Chia R. LEE, Kazuhide NAKAJIMA, Yoshihisa YANO, Tetsuhide TANIYAMA, Shuzo OTANI, Yoshiharu SHIMIZU, Shoji FUKUSHIMA

Author information

Toshio ICHIHARA
Hideki WANIBUCHI
Chyi Chia R. LEE
Kazuhide NAKAJIMA
Yoshihisa YANO
Tetsuhide TANIYAMA
Shuzo OTANI
Yoshiharu SHIMIZU
Shoji FUKUSHIMA
Author's Organization：
First Department of Pathology, 0saka City Universiry Medical School
First Department of Pathology, 0saka City Universiry Medical School
First Department of Pathology, 0saka City Universiry Medical School
Department of Environmental Microbiology, School of Environmental Health, Azabu Universiry
Second Department of Biochemistry, Osaka Ciry University Medical School
First Department of Pathology, 0saka City Universiry Medical School
Second Department of Biochemistry, Osaka Ciry University Medical Schoo
Department of Community Health, School of Medicine, Tokai Universiry
First Department of Pathology, 0saka City Universiry Medical School

Keywords: Medium-term bioassay system, Glutathione S-transferase

JOURNAL FREE ACCESS

1999 Volume 24 Issue 1 Pages 27-31

DOI https://doi.org/10.2131/jts.24.27

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Abstract

The effects of the 77 kDa Ju-myo protein, isolated from Drosophila melanogaster, on the development of glutathione S-transferase placental form (GST-P) positive foci in the male F344 rat liver were evaluated using a medium-term bioassay system. No modifying potential was evident in terms of the numbers or areas of GSTP positive foci. Ju-myo protein did not exert any influence on cell proliferation, as reflected by ornithine decarboxylase (ODC) or spermidine/spermine N¹-acetyltransferase (SAT) activity and BrdU labeling. These results demonstrated that Ju-myo protein is unlikely to have inhibitory or promoting effects on rat liver carcinogenesis.

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