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Potentiometric Determination of Trace Amounts of Amantadine Using a Modified Carbon-Paste Electrode

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Abstract

A chemically modified carbon-paste electrode has been described for the sensitive and selective determination of amantadine. ß-Cyclodextrin was used as modifier. The electrode shows a sub-Nernstian response of 51.0 ± 1.0 mV decade–1 for amantadine in the concentration range of 6.3 × 10–10 - 7.1 × 10−7 M at 25°C. The optimum pH value was maintained at 4.5 using a 0.02 M acetate buffer. The limit of detection of the electrode was 6.3 × 10−10 M of amantadine. The electrode responded very rapidly (<60 s) to changes in the concentration of amantadine, and its lifetime was more than three months. The relative standard deviation of measurements for a 2.0 × 10−7 M of amantadine was 0.68% (n = 7). The application of a modified carbon-paste electrode to the determination of amantadine in its pharmaceutical preparations showed a relative error of 2%. The recovery of amantadine (2.5 × 10−8 M) from a blood-serum sample was 94%.

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References

  1. A. M. Rudolph, R. A. Kamei, and K. J. Overby, “Rudolph’s Fundamentals of Pediatrics”, 2002, McGraw-Hill Professional, 308.

  2. Y. Kawaoka “Influenza Virology”, 2006, Caister Academic Press, Wymondham, UK, 169.

    Google Scholar 

  3. C. Shuangjin, F. Fang, L. Han, and M. Ming, J. Pharm. Biomed. Anal., 2007, 44, 1100.

    Article  PubMed  Google Scholar 

  4. Y. Higashi, I. Uemori, and Y. Fujii, Biomed. Chromatogr., 2005, 19, 655.

    Article  CAS  PubMed  Google Scholar 

  5. T. Iwata, H. Fujino, J. Sonoda, and M. Yamaguchi, Anal. Sci., 1997, 13, 467.

    Article  CAS  Google Scholar 

  6. D. Rakestraw, J. Pharm. Biomed. Anal., 1993, 11, 699.

    Article  CAS  PubMed  Google Scholar 

  7. N. T. Abdel-Ghani, A. F. Shoukry, and S. H. Hussein, J. Pharm. Biomed. Anal., 2002, 30, 601.

    Article  CAS  PubMed  Google Scholar 

  8. C. G. Amorim, A. N. Araujo, M. C. B. S. M. Montenegro, and V. L. Silva, Electroanalysis, 2007, 19, 2227.

    Article  CAS  Google Scholar 

  9. A. A. Salem, Can. J. Anal. Sci. Spectrosc., 2005, 50, 147.

    CAS  Google Scholar 

  10. R.-I. Stefan van Staden and A. A. Rat’ko, Talanta, 2006, 69, 1049.

    Article  Google Scholar 

  11. R.-I. Stefan van Staden and T. R. Mashile, Sens. Actuators, B, 2006, 120, 295.

    Article  Google Scholar 

  12. R.-I. Stefan, R. M. Nejema, J. F. van Staden, and H. Y. Aboul-Enein, Sens. Actuators, B, 2005, 106, 791.

    Article  CAS  Google Scholar 

  13. M. V. Rekharsky and Y. Inoue, Chem. Rev., 1998, 98, 1875.

    Article  CAS  PubMed  Google Scholar 

  14. K. A. Connors, Chem. Rev., 1997, 97, 1325.

    Article  CAS  PubMed  Google Scholar 

  15. R. I. Gelb, L. M. Schwartz, and D. A. Laufer, J. Chem. Soc., Perkin Trans. II, 1984, 15.

  16. E. Bakker and E. Pretsch, Anal. Chem., 2002, 420A.

  17. E. Bakker and E. Pretsch, TrAC, 2005, 24, 199.

    CAS  PubMed  Google Scholar 

  18. J. Sutter, A. Radu, S. Peper, E. Bakker, and E. Pretsch, Anal. Chim. Acta, 2004, 523, 53.

    Article  CAS  Google Scholar 

  19. K. Odashima, H. Hashimoto, and Y. Umezawa, Michrochim. Acta, 1994, 113, 223.

    Article  CAS  Google Scholar 

  20. E. Bakker, P. Buhlmann, and E. Pretsch, Chem. Rev., 1997, 97, 3083.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Razi University, Kermanshah, Iran

    F. Jalali & R. Maghooli

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  1. F. Jalali
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  2. R. Maghooli
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Correspondence to F. Jalali.

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Jalali, F., Maghooli, R. Potentiometric Determination of Trace Amounts of Amantadine Using a Modified Carbon-Paste Electrode. ANAL. SCI. 25, 1227–1230 (2009). https://doi.org/10.2116/analsci.25.1227

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  • DOI: https://doi.org/10.2116/analsci.25.1227

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