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Rapid detection of illegally added nifedipine in Chinese traditional patent medicine by surface-enhanced Raman spectroscopy

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Abstract

Nifedipine is an antihypertensive chemical. The illegal addition of this chemical into Chinese traditional patent medicine (CTPM) is unstandardized and lacks regulation. It could bring serious side effects to patients, causing various symptoms. Therefore, accurate detection of nifedipine is very important for human health and the prevention of illegal additives. Surface-enhanced Raman spectroscopy (SERS) is a fast and sensitive fingerprint spectroscopic technique, which has been shown to be promising in drug detection. In this study, nifedipine in CTPM was determined qualitatively and quantitatively with SERS. Linear relationships between the concentrations of nifedipine and the intensities of the characteristic peaks were established. The results showed a linear relationship within the concentration range of 0.5–10 mg/L, and the lowest detectable concentration of nifedipine in CTPM was 0.1 mg/L (equivalent to 0.03% doping of nifedipine in CTPM). This method has shown a great potential in the detection of drugs illegally added to CTPM.

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Acknowledgements

This research was supported by the National Key R&D Program of China (No. 2017YFC0110200), National Natural Science Foundation of China (NSFC, No. 61805143), Shanghai Sailing Program (No. 18YF1409500).

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Authors and Affiliations

  1. Shanghai Key Laboratory of Modern Optical Systems, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China

    Yanbing Yuan, Ning Chen, Luyao Wang, Hui Chen & Pei Ma

  2. Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China

    Xuedian Zhang

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  1. Yanbing Yuan
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  2. Ning Chen
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  3. Luyao Wang
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  4. Xuedian Zhang
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Correspondence to Pei Ma.

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Advanced Publication Released Online by J-STAGE November 19, 2021.

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Yuan, Y., Chen, N., Wang, L. et al. Rapid detection of illegally added nifedipine in Chinese traditional patent medicine by surface-enhanced Raman spectroscopy. ANAL. SCI. 38, 359–368 (2022). https://doi.org/10.2116/analsci.21P148

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  • DOI: https://doi.org/10.2116/analsci.21P148

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