Skip to main content
SpringerLink
Log in

Cell Analysis on Microfluidics Combined with Mass Spectrometry

  • Reviews
  • Published:
Analytical Sciences Aims and scope Submit manuscript

Abstract

Cell analysis is of great significance for the exploration of human diseases and health. However, there are not many techniques for high-throughput cell analysis in the simulated cell microenvironment. The high designability of the microfluidic chip enables multiple kinds of cells to be co-cultured on the chip, with other functions such as sample preprocessing and cell manipulation. Mass spectrometry (MS) can detect a large number of biomolecules without labelling. Therefore, the application of the microfluidic chip coupled with MS has represented a major branch of cell analysis over the past decades. Here, we concisely introduce various microfluidic devices coupled with MS used for cell analysis. The main functions of microfluidic devices are described first, followed by introductions of different interfaces with different types of MS. Then, their various applications in cell analysis are highlighted, with an emphasis on cell metabolism, drug screening, and signal transduction. Current limitations and prospective trends of microfluidics coupled with MS are discussed at the end.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Q. Chen, G. Liu, S. Liu, H. Su, Y. Wang, J. Li, and C. Luo, Trends Pharmacol. Sci., 2018, 39, 59.

    Article  PubMed  Google Scholar 

  2. C. Roma-Rodrigues, R. Mendes, P. V. Baptista, and A. R. Fernandes, Int. J. Mol. Sci., 2019, 20, 840.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. S. R. Singh, P. Rameshwar, and P. Siegel, Cancer Lett., 2016, 380, 203.

    Article  CAS  PubMed  Google Scholar 

  4. S. Xiao, J. R. Coppeta, H. B. Rogers, B. C. Isenberg, J. Zhu, S. A. Olalekan, K. E. McKinnon, D. Dokic, A. S. Rashedi, D. J. Haisenleder, S. S. Malpani, C. A. Arnold Murray, K. W. Chen, M. Y. Jiang, L. Bai, C. T. Nguyen, J. Y. Zhang, M. M. Laronda, T. J. Hope, K. P. Maniar, M. E. Pavone, M. J. Avram, E. C. Sefton, S. Getsios, J. E. Burdette, J. J. Kim, J. T. Borenstein, and T. K. Woodruff, Nat. Common., 2017, 8, 14584.

    Article  CAS  Google Scholar 

  5. M. K. Alam, E. Koomson, H. Zou, C. Yi, C. W. Li, T. Xu, and M. Yang, Anal. Chim. Acta, 2018, 1044, 29.

    Article  CAS  PubMed  Google Scholar 

  6. B. M. Maoz, A. Herland, E. A. FitzGerald, T. Grevesse, C. Vidoudez, A. R. Pacheco, S. P. Sheehy, T. E. Park, S. Dauth, R. Mannix, N. Budnik, K. Shores, A. Cho, J. C. Nawroth, D. Segre, B. Budnik, D. E. Ingber, and K. K. Parker, Nat. Biotechnol., 2018, 36, 865.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. E. V. Moiseeva, A. A. Fletcher, and C. K. Harnett, Sens. Actuators, B, 2011, 155, 408.

    Article  CAS  Google Scholar 

  8. C. Chen, C. Zhu, Y. Huang, Y. Nie, J. Yang, R. Shen, and D. Sun, Carbohydr. Polym., 2016, 137, 271.

    Article  CAS  PubMed  Google Scholar 

  9. N. Li, W. Zhang, Y. Li, and J.-M. Lin, TrAC, Trends Anal. Chem., 2019, 117, 200.

    Article  CAS  Google Scholar 

  10. J. Leipert and A. Tholey, Lab Chip, 2019, 19, 3490.

    Article  CAS  PubMed  Google Scholar 

  11. Q. Huang, H. Li, X. Dai, D. Zhao, B. Guan, and W. Xia, Mol. Med. Rep., 2019, 20, 3959.

    CAS  PubMed  Google Scholar 

  12. H.-F. Li, J. Liu, Z. Cai, and J.-M. Lin, Electrophoresis, 2008, 29, 1889.

    Article  CAS  PubMed  Google Scholar 

  13. H. Wei, H. Li, and J.-M. Lin, J. Chromatogr. A, 2009, 1216, 9134.

    Article  CAS  PubMed  Google Scholar 

  14. D. Gao, J. Liu, H. B. Wei, H. F. Li, G. S. Guo, and J. M. Lin, Anal. Chim. Acta, 2010, 665, 7.

    Article  CAS  PubMed  Google Scholar 

  15. Q. Chen, Z. He, W. Liu, X. Lin, J. Wu, H. Li, and J. M. Lin, Adv. Healthc. Mater., 2015, 4, 2291.

    Article  CAS  PubMed  Google Scholar 

  16. J. Liu, H. Wang, N. E. Manicke, J.-M. Lin, R. G. Cooks, and Z. Ouyang, Anal. Chem., 2010, 82, 2463.

    Article  CAS  PubMed  Google Scholar 

  17. D. Gao, H. B. Wei, G. S. Guo, and J. M. Lin, Anal. Chem., 2010, 82, 5679.

    Article  CAS  PubMed  Google Scholar 

  18. H. Wei, B.-h. Chueh, H. Wu, E. W. Hall, C.-w. Li, R. Schirhagl, J.-M. Lin, and R. N. Zare, Lab Chip, 2011, 11, 238.

    Article  CAS  PubMed  Google Scholar 

  19. H. H. Zhou, J. Castro-Perez, M. E. Lassman, T. Thomas, W. Y. Li, T. McLaughlin, X. Dan, P. Jumes, J. A. Wagner, D. E. Gutstein, B. K. Hubbard, D. J. Rader, J. S. Millar, H. N. Ginsberg, G. Reyes-Soffer, M. Cleary, S. F. Previs, and T. P. Roddy, Rapid Commun. Mass Spectrom., 2013, 27, 1294.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. M. Yang, T. C. Chao, R. Nelson, and A. Ros, Anal. Bioanal. Chem., 2012, 404, 1681.

    Article  CAS  PubMed  Google Scholar 

  21. G. J. LaBonia, K. R. Ludwig, C. B. Mousseau, and A. B. Hummon, Anal. Chem., 2018, 90, 1423.

    Article  CAS  PubMed  Google Scholar 

  22. Q. Chen, J. Wu, Y. Zhang, and J.-M. Lin, Anal. Chem., 2012, 84, 1695.

    Article  CAS  PubMed  Google Scholar 

  23. S. Mao, J. Zhang, H. Li, and J. M. Lin, Anal. Chem., 2013, 85, 868.

    Article  CAS  PubMed  Google Scholar 

  24. H. Wei, H. Li, S. Mao, and J. M. Lin, Anal. Chem., 2011, 83, 9306.

    Article  CAS  PubMed  Google Scholar 

  25. J. Zhang, J. Wu, H. Li, Q. Chen, and J. M. Lin, Biosens. Bioelectron., 2015, 68, 322.

    Article  CAS  PubMed  Google Scholar 

  26. W. Liu and J. M. Lin, ACS Sens., 2016, 1, 344.

    Article  CAS  Google Scholar 

  27. A. Folch and M. Toner, Biotechnol. Prog., 1998, 14, 388.

    Article  CAS  PubMed  Google Scholar 

  28. J. Dou, S. Mao, H. Li and J.-M. Lin, Anal. Chem., 2020, 92, 892.

    Article  CAS  PubMed  Google Scholar 

  29. S. Feng, S. Mao, Q. Zhang, W. Li, and J. M. Lin, ACS Sens, 2019, 4, 521.

    Article  CAS  PubMed  Google Scholar 

  30. E. Leclerc, Y. Sakai, and T. Fujii, Biomed. Microdevices, 2003, 5, 109.

    Article  CAS  Google Scholar 

  31. S. M. Ong, C. Zhang, Y. C. Toh, S. H. Kim, H. L. Foo, C. H. Tan, D.. van Noort, S. Park, and H. Yu, Biomaterials, 2008, 29, 3237.

    Article  CAS  PubMed  Google Scholar 

  32. Y. C. Toh, C. Zhang, J. Zhang, Y. M. Khong, S. Chang, V. D. Samper, D.. van Noort, D. W. Hutmacher, and H. Yu, Lab Chip, 2007, 7, 302.

    Article  CAS  PubMed  Google Scholar 

  33. H. Liu, M. Jie, Z. He, H. F. Li, and J. M. Lin, Anal. Chim. Acta, 2017, 978, 1.

    Article  CAS  PubMed  Google Scholar 

  34. R. Booth and H. Kim, Lab Chip, 2012, 12, 1784.

    Article  CAS  PubMed  Google Scholar 

  35. S. W. L. Lee, M. Campisi, T. Osaki, L. Possenti, C. Mattu, G. Adriani, R. D. Kamm, and V. Chiono, Adv. Healthc. Mater., 2020, 9, 1901486.

    Article  CAS  Google Scholar 

  36. S. G. Mun, H. W. Choi, J. M. Lee, J. H. Lim, J. H. Ha, M. J. Kang, E. J. Kim, L. Kang, and B. G. Chung, Nano Converg., 2020, 7, 10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. S. I. Ahn, Y. J. Sei, H. J. Park, J. Kim, Y. Ryu, J. J. Choi, H. J. Sung, T. J. MacDonald, A. I. Levey, and Y. Kim, Nat. Common., 2020, 11, 175

    Article  CAS  Google Scholar 

  38. D. Huh, B. D. Matthews, A. Mammoto, M. Montoya-Zavala, H. Y. Hsin, and D. E. Ingber, Science, 2010, 328, 1662.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. B. A. Hassell, G. Goyal, E. Lee, A. Sontheimer-Phelps, O. Levy, C. S. Chen, and D. E. Ingber, Cell Rep., 2017, 21, 508.

    Article  CAS  PubMed  Google Scholar 

  40. A. Sontheimer-Phelps, B. A. Hassell, and D. E. Ingber, Nat. Rev. Cancer, 2019, 19, 65.

    Article  CAS  PubMed  Google Scholar 

  41. L. Vernetti, A. Gough, N. Baetz, S. Blutt, J. R. Broughman, J. A. Brown, J. Foulke-Abel, N. Hasan, J. In, E. Kelly, O. Kovbasnjuk, J. Repper, N. Senutovitch, J. Stabb, C. Yeung, N. C. Zachos, M. Donowitz, M. Estes, J. Himmelfarb, G. Truskey, J. P. Wikswo, and D. L. Taylor, Sci. Rep., 2017, 7, 42296.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. M. S. Woolf, L. M. Dignan, II. M. Lewis, C. J. Tomley, A. Q. Nauman, and J. P. Landers, Lab Chip, 2020, 20, 1426.

    Article  CAS  PubMed  Google Scholar 

  43. T. Xie, N. Li, S. Mao, Q. Zhang, and J. M. Lin, ACS Omega, 2020, 5, 3857.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. M. A. Unger, H. P. Chou, T. Thorsen, A. Scherer, and S. R. Quake, Science, 2000, 288, 113.

    Article  CAS  PubMed  Google Scholar 

  45. S. Quake and I. Ieee, in Ieee Leos International Conference on Optical Mems, 2000, Kauai, III, USA, 55.

  46. E. A. Ottesen, J. W. Hong, S. R. Quake, and J. R. Leadbetter, Science, 2006, 314, 1464.

    Article  CAS  PubMed  Google Scholar 

  47. D. Di Carlo, N. Aghdam, and L. P. Lee, Anal. Chem., 2006, 78, 4925.

    Article  CAS  PubMed  Google Scholar 

  48. Q. Huang, S. Mao, M. Khan, and J. M. Lin, Analyst, 2019, 144, 808.

    Article  CAS  PubMed  Google Scholar 

  49. M. Rothbauer, V. Charwat, and P. Ertl, in “Microarray Technology: Methods and Applications”, ed. P. C. H. Li, A. Sedighi, and L. Wang, 2016, Humana Press Inc, Totowa, 273.

  50. Y. Song, Y. Shi, M. Huang, W. Wang, Y. Wang, J. Cheng, Z. Lei, Z. Zhu, and C. Yang, Angew. Chem., Int. Ed., 2019, 58, 2236.

    Article  CAS  Google Scholar 

  51. F. Chen, L. Lin, J. Zhang, Z. He, K. Uchiyama, and J. M. Lin, Anal. Chem., 2016, 88, 4354.

    Article  CAS  PubMed  Google Scholar 

  52. B. L. Wang, A. Ghaderi, H. Zhou, J. Agresti, D. A. Weitz, G. R. Fink, and G. Stephanopoulos, Nat. Biotechnol., 2014, 32, 473.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. E. Brouzes, M. Medkova, N. Savenelli, D. Marran, M. Twardowski, J. B. Hutchison, J. M. Rothberg, D. R. Link, N. Perrimon, and M. L. Samuels, Proc. Natl. Acad. Sci. U. S. A., 2009, 106, 14195.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. J. Zhai, S. H. Yi, Y. W. Jia, P. I. Mak, and R. P. Martins, TrAC, Trends Anal. Chem., 2019, 117, 231.

    Article  CAS  Google Scholar 

  55. S. Mao, W. Zhang, Q. IIuang, M. Khan, H. Li, K. Uchiyama, and J. M. Lin, Angew. Chem. Int. Ed. Engl., 2018, 57, 236.

    Article  CAS  PubMed  Google Scholar 

  56. S. Mao, Q. Zhang, H. Li, W. Zhang, Q. Huang, M. Khan, and J. M. Lin, Chem. Sci., 2018, 9, 7694.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. S. Mao, Q. Zhang, W. Liu, Q. Huang, M. Khan, W. Zhang, C. Lin, K. Uchiyama, and J. M. Lin, Chem. Sci., 2019, 10, 2081.

    Article  CAS  PubMed  Google Scholar 

  58. P. Liu, Q. Huang, M. Khan, N. Xu, H.-R. Yao, and J.-M. Lin, Anal. Chem., 2020, 92, 7900.

    Article  CAS  PubMed  Google Scholar 

  59. I. M. Lazar, “Microfluidic Electrophoresis: Methods and Protocols”, 2019, DUTTA D. New York, NY, Springer New York, 225.

    Google Scholar 

  60. X. Li, H. Hu, S. Zhao, and Y.-M. Liu, Anal. Chem., 2016, 88, 5338.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. P. Hoffmann, U. Haeusig, P. Schulze, and D. Belder, Angew. Chem. Int. Ed., 2007, 46, 4913.

    Article  CAS  Google Scholar 

  62. J. Lee, S. A. Soper, and K. K. Murray, J. Mass Spectrom., 2009, 44, 579.

    Article  CAS  PubMed  Google Scholar 

  63. R. D. Oleschuk and D. J. Harrison, TrAC, Trends Anal. Chem., 2000, 19, 379.

    Article  CAS  Google Scholar 

  64. H. Chun, J. Chromatogr. A, 2018, 1543, 67.

    Article  CAS  PubMed  Google Scholar 

  65. A.-C. Louer, A. Plecis, A. Pallandre, J.-C. Galas, A. Estevez-Torres, and A.-M. Haghiri-Gosnet, Anal. Chem., 2013, 85, 7948.

    Article  CAS  PubMed  Google Scholar 

  66. D. Gao, H. Liu, J.-M. Lin, Y. Wang, and Y. Jiang, Lab Chip, 2013, 13, 978.

    Article  CAS  PubMed  Google Scholar 

  67. W. Zhang, N. Li, L. Lin, Q. Huang, K. Uchiyama, and J. M. Lin, Small, 2020, 16, e1903402.

    Article  PubMed  Google Scholar 

  68. D. J. Steyer and R. T. Kennedy, Anal. Chem., 2019, 91, 6645.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. D. A. Holland-Moritz, M. K. Wismer, B. F. Mann, I. Farasat, P. Devine, E. D. Guetschow, I. Mangion, C. J. Welch, J. C. Moore, S. Sun, and R. T. Kennedy, Angew. Chem. Int. Ed., 2020, 59, 4470.

    Article  CAS  Google Scholar 

  70. Q. Chen, Z. He, W. Liu, X. Lin, J. Wu, H. Li, and J.-M. Lin, Adv, Healthc. Mater., 2015, 4, 2291.

    Article  CAS  PubMed  Google Scholar 

  71. Y. Zheng, Z. Wu, J.-M. Lin, and L. Lin, Chin. Chem. Lett., 2020, 31, 451.

    Article  CAS  Google Scholar 

  72. J. Lee, S. A. Soper, and K. K. Murray, Rapid Commun. Mass Spectrom., 2011, 25, 693.

    Article  CAS  PubMed  Google Scholar 

  73. C.-W. Tsao, S. Tao, C.-F. Chen, J. Liu, and D. L. DeVoe, Microfluid. Nanofluid., 2010, 8, 777.

    Article  CAS  Google Scholar 

  74. C. W. Tsao, I. C. Lei, P. Y. Chen, and Y. L. Yang, Analyst, 2018, 143, 981.

    Article  CAS  PubMed  Google Scholar 

  75. T. Hatakeyama, D. L. Chen, and R. F. Ismagilov, J. Am. Chem. Soc., 2006, 128, 2518.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. D. Momotenko, L. Qiao, F. Cortes-Salazar, A. Lesch, G. Wittstock, and H. H. Girault, Anal. Chem., 2012, 84, 6630.

    Article  CAS  PubMed  Google Scholar 

  77. S. K. Kuester, S. R. Fagerer, P. E. Verboket, K. Eyer, K. Jefimovs, R. Zenobi, and P. S. Dittrich, Anal. Chem., 2013, 85, 1285.

    Article  Google Scholar 

  78. K. Mesbah, R. Thai, S. Bregant, and F. Malloggi, Sci. Rep., 2017, 7, 6756.

    Article  PubMed  PubMed Central  Google Scholar 

  79. S. Weidmann, S. Kemmerling, S. Mädler, H. Stahlberg, T. Braun, and R. Zenobi, Eur. J. Mass Spectrom., 2012, 18, 279.

    Article  CAS  Google Scholar 

  80. J. Yang, J. Zhu, R. Pei, J. A. Oliver, D. W. Landry, M. N. Stojanovic, and Q. Lin, Anal. Methods, 2016, 8, 5190.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. A. Quaranta, A. Sroka-Bartnicka, E. Tengstrand, and G. Thorsén, Anal. Bioanal. Chem., 2016, 408, 4765.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. L. Nie, G.-B. Xu, X.-Y. Wang, Y. Liu, and P.-Y. Yang, Chin. Chem. Lett., 2013, 24, 491.

    Article  CAS  Google Scholar 

  83. S. Mikkonen, J. Jacksen, J. Roeraade, W. Thormann, and A. Emmer, Anal. Chem., 2016, 88, 10044.

    Article  CAS  PubMed  Google Scholar 

  84. M. Yang, R. Nelson, and A. Ros, Anal. Chem., 2016, 88, 6672.

    Article  CAS  PubMed  Google Scholar 

  85. S. V.. de Freitas, F. R.. de Souza, J. C. Rodrigues Neto, G. A. Vasconcelos, P. V. Abdelnur, B. G. Vaz, C. S. Henry, and W. K. T. Coltro, Anal. Chem., 2018, 90, 11949.

    Article  PubMed  Google Scholar 

  86. W. Liu, N. Wang, X. Lin, Y. Ma, and J. M. Lin, Anal. Chem., 2014, 86, 7128.

    Article  CAS  PubMed  Google Scholar 

  87. J. Wu, S. Wang, Q. Chen, H. Jiang, S. Liang, and J. M. Lin, Anal. Chim. Acta, 2015, 892, 132.

    Article  CAS  PubMed  Google Scholar 

  88. W. Liu, Q. Chen, X. Lin, and J. M. Lin, Analyst, 2015, 140, 1551.

    Article  CAS  PubMed  Google Scholar 

  89. Z. H. Zhong, S. F. Mao, H. F. Lin, H. F. Li, J. H. Lin, and J. M. Lin, Talanta, 2019, 204, 6.

    Article  CAS  PubMed  Google Scholar 

  90. W. Liu and J.-M. Lin, ACS Sensors, 2016, 1, 344.

    Article  CAS  Google Scholar 

  91. M. Jender, P. Novo, D. Maehler, U. Munchberg, D. Janasek, and E. Freier, Anal. Chem., 2020, 92, 6764.

    Article  CAS  PubMed  Google Scholar 

  92. K. Wink, L. Mahler, J. R. Beulig, S. K. Piendl, M. Roth, and D. Belder, Anal. Bioanal. Chem., 2018, 410, 7679.

    Article  CAS  PubMed  Google Scholar 

  93. C. Y. Lee, Y. Fan, S. S. Rubakhin, S. Yoon, and J. V. Sweedler, Sci. Rep., 2016, 6, 26940.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. S. Mao, D. Gao, W. Liu, H. Wei, and J.-M. Lin, Lab Chip, 2012, 12, 219.

    Article  CAS  PubMed  Google Scholar 

  95. D. Gao, H. Li, N. Wang, and J. M. Lin, Anal. Chem., 2012, 84, 9230.

    Article  CAS  PubMed  Google Scholar 

  96. L. Lin, Y. Zheng, Z. Wu, W. Zhang, and J.-M. Lin, Chem. Commun., 2019, 55, 10218.

    Article  CAS  Google Scholar 

  97. M. S. Jie, H. F. Lin, Z. Y. He, H. Y. Liu, H. F. Li, and J. M. Lin, Sci. China: Chem., 2018, 61, 236.

    Article  CAS  Google Scholar 

  98. X. Shao, D. Gao, Y. Chen, F. Jin, G. Hu, Y. Jiang, and H. Liu, Anal. Chim. Acta, 2016, 934, 186.

    Article  CAS  PubMed  Google Scholar 

  99. C. Lin, L. Lin, S. Mao, L. Yang, L. Yi, X. Lin, J. Wang, Z. X. Lin, and J. M. Lin, Anal. Chem., 2018, 90, 10326.

    Article  CAS  PubMed  Google Scholar 

  100. F. Merlier, R. Jellali, and E. Leclerc, Analyst, 2017, 142, 3747.

    Article  CAS  PubMed  Google Scholar 

  101. S. Nahavandi, S. Y. Tang, S. Baratchi, R. Soffe, S. Nahavandi, K. Kalantar-Zadeh, A. Mitchell, and K. Khoshmanesh, Small, 2014, 10, 4810.

    Article  CAS  PubMed  Google Scholar 

  102. M. Zhong, C. Y. Lee, C. A. Croushore, and J. V. Sweedler, Lab Chip, 2012, 12, 2037.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. X. Li, R. Xu, X. Wei, H. Hu, S. Zhao, and Y. M. Liu, Anal. Chem., 2017, 89, 12014.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. Q. Zhuang, S. Wang, J. Zhang, Z. He, H. Li, Y. Ma, and J.-M. Lin, Sci. China: Chem., 2016, 59, 243.

    Article  CAS  Google Scholar 

  105. L. Lin, X. Lin, L. Lin, Q. Feng, T. Kitamori, J. M. Lin, and J. Sun, Anal. Chem., 2017, 89, 10037.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We acknowledge the financial support from the National Natural Science Foundation of China (Nos. 21727814, 81973569 and 21621003).

Author information

Authors and Affiliations

  1. Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China

    Wanling Zhang, Qiang Zhang & Jin-Ming Lin

Authors
  1. Wanling Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qiang Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jin-Ming Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jin-Ming Lin.

Additional information

Wanling Zhangis a PhD student in the research group of Prof. J.-M. Lin in the Department of Chemistry, Tsinghua University, China. She got her BS from the Department of Chemistry, Tsinghua University, China. Her current research focus is cell analysis on microfluidic devices coupled with mass spectrometry and fluorescence.

Qiang Zhangreceived his B. S. degree from the Department of Chemistry at Tsinghua University in 2017. He is currently a Ph.D. candidate under the instruction of Prof. J.-M. Lin at Tsinghua University. His is focusing on the development of open microfluidic methods for single cell manipulation including adhesion measurement and cell self-repair analysis.

Jin-Ming Linreceived his BS from Fuzhou University in 1984 and PhD from Tokyo Metropolitan University in 1997. He had studied and worked in Showa University and Tokyo Metropolitan University during 1992 - 2002. He is currently a professor of Department of Chemistry, Tsinghua University since 2004, and was selected as Cheung Kung Scholars Professor of Ministry of Education, China at 2008. He is a Fellow of Royal Chemical Society, a Supervisor of Chinese Chemical Society. His current research is focused on cell analysis, microfluidics with mass spectrometry, and chemiluminescence.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, W., Zhang, Q. & Lin, JM. Cell Analysis on Microfluidics Combined with Mass Spectrometry. ANAL. SCI. 37, 249–260 (2021). https://doi.org/10.2116/analsci.20R006

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2116/analsci.20R006

Keywords

Search

Navigation