Slugs can retain odor-taste associative memory for several weeks, and this requires protein synthesis. We examined the dose-dependency of the onset time of amnesia caused by the protein synthesis inhibitor anisomycin, and showed that with reduced dose, the onset is shifted from 2 days to 3 days after conditioning; we could not shift the onset delay later than 3 days. Our results suggest that the mechanism underling memory retention is different in the period up to 3 days, versus the period later than 3 days. Our results also suggest that sustained inhibition of protein synthesis in the period from zero to 3 hr after conditioning is necessary to cause amnesia.
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1 December 2004
Onset of Amnesia Is Delayed with a Decrease in Inhibition of Protein Synthesis during Odor-taste Associative Learning in the Terrestrial Slug Limax valentianus
Kikuo Yasui,
Ryota Matsuo,
Yutaka Kirino
anisomycin
Limax
long-term memory
onset of amnesia
protein synthesis inhibition