Molecular-genetic mechanisms of treatment of urogenital infections in pregnant women

Authors / Institutions

Karaulov A. Viktorovich / I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

S.S.Afanas’ev / G.N.Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Supervision Service for Consumer Rights Protection and People’s Welfare, Moscow, Russian Federation

Vladimir A. Aleshkin / G.N.Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Supervision Service for Consumer Rights Protection and People’s Welfare, Moscow, Russian Federation

N.L.Bondarenko / I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

Elena A. Voropaeva / G.N.Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Supervision Service for Consumer Rights Protection and People’s Welfare, Moscow, Russian Federation

M.S.Afanas’ev / I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

A.L.Pylev / I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

Olga Yu. Borisova / G.N.Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Supervision Service for Consumer Rights Protection and People’s Welfare, Moscow, Russian Federation

Andrey V. Aleshkin / G.N.Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Supervision Service for Consumer Rights Protection and People’s Welfare, Moscow, Russian Federation

Yu.N.Urban / G.N.Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Supervision Service for Consumer Rights Protection and People’s Welfare, Moscow, Russian Federation

Anastasiya B. Borisova / G.N.Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Supervision Service for Consumer Rights Protection and People’s Welfare, Moscow, Russian Federation

A.D.Voropaev / G.N.Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Supervision Service for Consumer Rights Protection and People’s Welfare, Moscow, Russian Federation

The systematic review provides the recent literature data, reflecting the current scientific and practical trends in the treatment of urogenital infections (UGI) of pregnant women, based on the leading role of the factors and components of innate and adaptive immunity in the occurrence, development, and completion of the pathological processes in infectious and noninfectious diseases. The currently defined pathogenetic molecular-genetic mechanisms of the development of UGI in pregnant women cause the need for personalized treatment aimed at the correction of detected defects in the TLRs system: violation of ligand recognition, TLRs gene expression, signal transduction, elaboration of effector molecules, and TLRs gene polymorphism. Highly sensitive and highly specific methods of molecular genetic diagnosis, assessing the levels of molecular genetic predictors and biomarkers allow quickly and with a high degree of reliability to verify the etiology of infectious and noninfectious diseases, to comprehensively assess genetic predisposition to the development of disease and the transcription profiles of the markers of inflammatory response, a pathogenetic role of TLRs in each case. The nature of the above-mentioned defects in the TLRs system and their severity is judged by the detected levels of biomarkers (including the TLRs expression levels in the organs and tissues of the body) and adequate personalized therapy with the obligatory inclusion of common anti-microbial and immunobiological drugs (serum immunoglobulins, probiotics), and immunomodulators (preferably with preliminary identification of antimicrobial properties and ability to interact with TLRs as agonists, antagonists or modifiers of signaling pathways).
Key words: urogenital infection in pregnant women, inflammatory response, infectious agents, factors of innate immunity, TLRs-molecular genetic predictors and biomarkers of human health, personalized therapy.
For citation: Karaulov A.V., Afanas’ev S.S., Aleshkin V.A., Bondarenko N.L., Voropaeva E.A., Afanas’ev M.S., Pylev L.A., Borisova O.Yu., Aleshkin A.V.,
Urban Yu.N., Borisova A.B., Voropaev A.D. Molecular-genetic mechanisms of treatment of urogenital infections in pregnant women. Vopr. urol. androl. (Urology and Andrology). 2019; 7(2): 12–22. (In Russian). DOI: 10.20953/2307-6631-2019-2-12-22