Clinical and laboratory characteristics of the course and outcomes of rotavirus infection in patients with comorbidities

Authors / Institutions

Aleksandr V. Gorelov / I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation / Central Research Institute of Epidemiology of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation

N.B.Denisyuk / Orenburg State Medical University, Orenburg, Russian Federation

Objective. To analyze clinical and laboratory characteristics of the course and outcomes of rotavirus infection (RVI) in patients with comorbidities
Patients and methods. This study included 45 children with various comorbidities: 15 children with primary ketoacidosis, 15 children with cerebral palsy, and 15 preterm infants. We used clinical, biochemical, bacteriological, and instrumental methods of examination. RVI was confirmed by detection of rotavirus antigen in feces using ELISA tests.
Results. Gestational toxicosis, artificial feeding, and intestinal flora disorders were independent risk factors for RVI in children with comorbidities. In patients with primary ketoacidosis, vomiting was the cause of severe acetonuria upon admission (р = 0.005; χ2). Patients with cerebral palsy were more likely to have fever in the acute period of the disease (р < 0.001; χ2), which often caused seizures. Premature infants had diarrhea as a leading syndrome significantly more often than other participants (р = 0.028; χ2); it resulted in weight loss.
Conclusion. Rotavirus infection in children with comorbidities led to earlier and more severe manifestations of the main disease. Severe forms, such as toxicosis and dehydration were significantly more prevalent.
Key words: children, cerebral palsy, prematurity, primary ketoacidosis, rotavirus infection.

For citation: Gorelov A.V., Denisyuk N.B. Clinical and laboratory characteristics of the course and outcomes of rotavirus infection in patients with comorbidities. Vopr. prakt. pediatr. (Clinical Practice in Pediatrics). 2019; 14(4): 8–14. (In Russian).