Effects of 99mTc on the electrochemical properties of thiamazole in vitro

Authors

  • Safija Herenda University of Sarajevo, Faculty of Science
  • Anera Kazlagić University of Sarajevo, Faculty of Science
  • Edhem Hasković University of Sarajevo, Faculty of Science
  • Jelena Šćepanović Faculty of Metallurgy and Technology, University of Montenegro
  • Jasmina Marušić University "Vitez" Vitez

DOI:

https://doi.org/10.20450/mjcce.2021.2148

Abstract

Thiamazole inhibits the thyroid hormone synthesis and does not inactivate the existing thyroxine and triiodothyronine that circulate in the blood. In this paper Thiamazole electrochemical behavior was monitored by cyclic voltammetry on glassy carbon (GC) electrode in the absence and presence of sodium pertechnetate (99mTc). The influence of different Thiamazole concentrations without and in the presence of radiopharmaceutical 99mTc, the effect of the number of scan cycles, and the effect of 99mTc activity on the appearance of cyclic voltammograms were examined. The results show that there is an observed increase in the reduction peak current with an increase of Thiamazole concentration. It was found that the concentration of the tested drug had a significant effect on its redox characteristics. The results obtained show that the application of different concentrations of sodium pertechnetate exhibits the inhibitory properties of the used radiopharmaceutical on the drug in the treatment of thyroid gland disease.

Author Biographies

Safija Herenda, University of Sarajevo, Faculty of Science

Prof.dr.

Department of Chemistry

Anera Kazlagić, University of Sarajevo, Faculty of Science

Department of Chemistry

Assistant

Edhem Hasković, University of Sarajevo, Faculty of Science

Prof.dr.

Department of Biology

Jelena Šćepanović, Faculty of Metallurgy and Technology, University of Montenegro

Prof.dr.

Jasmina Marušić, University "Vitez" Vitez

Assistant

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Published

2021-05-11

How to Cite

Herenda, S., Kazlagić, A., Hasković, E., Šćepanović, J., & Marušić, J. (2021). Effects of 99mTc on the electrochemical properties of thiamazole in vitro. Macedonian Journal of Chemistry and Chemical Engineering, 40(1), 21–28. https://doi.org/10.20450/mjcce.2021.2148

Issue

Vol. 40 No. 1 (2021)

Section

Electrochemistry

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