Although rare, hypopigmentary disorders have been observed in many vertebrate species. These disorders include albinism, leucism, and piebaldism, and can be differentiated based on the pattern and degree of lack of pigmentation. For many species, these disorders persist in nature, suggesting that affected animals can survive and potentially reproduce. Here we report a case of albinism in a Jamaican fruit bat (Artibeus jamaicensis) captured from a cave dwelling in Cuba. In addition to describing this albino individual's morphological characteristics, we recorded acoustical parameters of echolocation calls during foraging in a flight chamber. We found that the albino individual emits high-frequency multi-harmonic calls with short durations, which are characteristic of this species and other phyllostomid bats. We discuss potential acoustical adaptations in albino bats that could facilitate their survival and suggest future approaches to studying these unique animals.