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KCI 후보

중증 근무력증에서 일어나는 신경근접합부의 면역병리학적 변화

Immunopathologic Change of Neuromuscular Junction in Myasthenia Gravis

대한근전도 전기진단의학회지
약어 : J Electrodiagn Neuromuscul Dis
2013 vol.15, no.1, pp.6 - 10
DOI : 10.18214/jkaem.2013.15.1.6
발행기관 : 대한근전도전기진단의학회
연구분야 : 재활의학
Copyright © 대한근전도전기진단의학회
김지영 1 ,  박기덕 2

1관동대학교 의과대학

2이화여자대학교

197 회 열람

The most essential phenomenon of myasthenia gravis (MG) is the impaired neuromuscular transmission caused by autoantibodies directed to proteins in the postsynaptic muscle membrane of the neuromuscular junction (NMJ). It is a highly specialized structure, which is designed to facilitate a chemical transmission from a motor nerve to a skeletal muscle. The integrity and efficiency of NMJ is attributed to a systematic interaction between acetylcholine receptor (AChR) and other synaptic proteins. Immunolopathologic process induced by autoantibodies attacks other AChR-associated synaptic proteins as well as the AChRs. Although the loss of the AChRs is a key feature of MG, the damage of AChR-associated synaptic proteins aggravates the pathologic process and delays the repair process. Therefore, ideally, the goal of therapy should be to improve the potential restoration process of NMJ as well as discontinue the abnormal autoimmune process.

Myasthenia gravis, Neuromuscular junction, Autoimmune diseases, Autoantibodies, Proteins

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